The annual prize is one of the most prestigious museum awards in the world and 17�Թ��� Museum, part of 17�Թ���, is the first university museum to receive it, earning recognition for the way it balances globally-significant academic research with community engagement and social responsibility. 

Judges praised how 17�Թ��� Museum has ‘reimagined its mission, acknowledging and addressing its complex history by redefining the role of its collections and public programmes.’ Its approach to co-curation was cited as part of this, working with local and diasporic communities to bring new perspectives to collections and challenge traditional narratives. The South Asia Gallery, a British Museum partnership, is a key element of this, co-curated with 30 inspiring community members from across the South Asian diaspora, who were able to tell their own stories in their own words and on their own terms. 

17�Թ��� Museum was also praised for ‘thoughtful, informed, and impactful community engagement, creating a truly inclusive space where all individuals, regardless of identity or background, can see themselves reflected and represented.’ The 17�Թ��� Museum Celebrates programme of events, created in collaboration with charities, faith organisations and community activists, aims to build understanding between cultures, bringing people together to celebrate culturally-significant events such as Lunar New Year, Vaisakhi, Africa Day and Iftar. 

Meanwhile, the Museum’s Top Floor has been transformed into a social and environmental justice hub, creating a space for collaboration with charities and non-profit organisations helping Greater 17�Թ���’s communities take action on the issues they care about. It acts as the headquarters for Pinc College, a specialist creative education college for neurodivergent young people, aged 16 to 24. 

These initiatives are part of a wider, values-led transformation, underpinned by a £15 million redevelopment, which was completed in February 2023. 

Operated by the European Museum Forum (EMF), EMYA recognises new or redeveloped museums that showcase the best in excellence and innovation in their field. It aims to recognise museums that promote inter-cultural dialogue and community participation, demonstrate a commitment to sustainability, and show creative and imaginative approaches to the production of knowledge. 

Previous winners include Sámi Museum Siida in Northern Lapland, Finland, Naturalis Biodiversity Center in Leiden, Netherlands, Rijksmuseum Amsterdam, The Design Museum in London, and Guggenheim Museum Bilbao. 

17�Թ��� Museum won the main prize in the face of competition from 41 other shortlisted museums from across the continent. The award was presented on Saturday 25 May, during the EMYA2025 Annual Conference and Awards Ceremony at the Sybir Memorial Museum in Białistok, Poland on 25 May 2025. 

Senior author Dr Ben Brown is a practicing GP and co-founder of Patchs, as well as a researcher at 17�Թ���. He said: “AI has the potential to reduce the heavier workload which is sometimes associated with eVisits in general practice.

“Despite the potential, AI tools are not yet routinely used in primary care. This study is the first to ask if this use of AI would be acceptable to staff and patients.”

Co-author Professor Niels Peek from The Healthcare Improvement Studies Institute, University of Cambridge said: “This work aligns with the government’s strategy to address the high workload that the NHS is facing with technology.

“The study demonstrates that there exist opportunities to streamline NHS services with AI in a way that is meaningful for, and would be welcomed by, patients and staff.”

A delegation from the University visited the country this week to develop our first education partnership in India, with the Birla Institute of Technology and Science (BITS), Pilani. The two universities will establish a range of learning opportunities for students from BITS Pilani in the fields of engineering and computer science.

Two new research partnerships have been launched this week with the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) and the Manipal Academy of Higher Education (MAHE). Agreements have been signed by both institutions to mark the start of seed corn funds, which will help to create research projects addressing shared interests in India and the UK.

Professor Stephen Flint, Associate Vice-President International at 17�Թ��� and leader of the University’s visiting delegation, said: “As 17�Թ��� enters its third century, these exciting new partnerships both deepen and broaden our relationship with India. India is a key global partner, and we are incredibly proud of our joint educational ventures and commitment to academic collaboration over the years, which we know will continue for many more.”

Professor Ramgopal Rao, Vice Chancellor at the Birla Institute of Technology and Science, Pilani said: “This Memorandum of Understanding marks a significant milestone for BITS Pilani as we strengthen our commitment to providing world-class education and research opportunities.

“By partnering with a globally renowned institution like 17�Թ���, we are confident that we can create transformative learning experiences for our students and contribute to cutting-edge research that addresses pressing global challenges.”

Lt. Gen. (Dr.) MD Venkatesh, Vice-Chancellor at the Manipal Academy of Higher Education (MAHE) said: “We are delighted to welcome the delegation from 17�Թ��� to MAHE, Manipal, and sign the Memorandum of Understanding. This collaboration reflects our shared commitment to advancing research, fostering innovation, and creating new opportunities for students and faculty across both institutions.

“We look forward to deepening our engagement through joint research initiatives, co-supervised PhDs, and academic exchange programmes, especially in healthcare, biological sciences, and engineering. Together, we aim to drive impactful outcomes that benefit our academic communities and society at large.”

Professor G.U. Kulkarni, President at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) said: “The signing of this Letter of Intent marks an important step toward strengthening research collaboration between both institutions, particularly in the field of materials science. The collaboration will enable both institutions, known for their academic excellence, to derive benefits from synergy between them and be a fruitful platform for new initiatives.”

These new partnerships build upon the University’s established relationships with the Indian Institute of Technology Kharagpur (IIT Kharagpur), Indian Institute of Science (IISc), Ashoka University, and O.P. Jindal Global University.

17�Թ��� was the first UK university to launch a joint PhD programme with an Indian institution, the dual award PhD with IIT Kharagpur, in 2021. Today, the University’s joint programmes with IIT Kharagpur and IISc nurture early career scholars from across India.

17�Թ��� also works closely with industry partners in India. A long-standing relationship with Tata Steel has seen the establishment of a Centre for Innovation in Advanced Materials at the Henry Royce Institute, which is focused on medical, 2D and second-life materials to emphasise the importance of reusing and recycling resources.

The conference on 29-30 May will bring together world experts in Dante studies, early print culture, and digital humanities. Attendees will explore groundbreaking interdisciplinary research, including the project’s pioneering use of artificial intelligence and computer vision to analyse page design and layout in early modern books - offering a new lens through which to view the evolution of print culture.

The JRRIL Dante Collection includes all but three of the known pre-1650 printed editions of the Divine Comedy, with highlights such as the very first Italian editions printed in 1472, richly illustrated editions from 1481 and 1487, and later translations in Spanish, French, English and Japanese. The collection also features 19th-century illustrations by Gustave Doré, and a giant hand-illuminated manuscript created in 1902.

The 17�Թ��� Digital Dante Library is hosted on 17�Թ��� Digital Collections, a state-of-the-art platform developed in partnership with Cambridge University Library and supported by the Research Lifecycle Project. It exemplifies a new model for digital scholarship, merging humanities research with advanced imaging techniques and setting a new standard for cultural heritage digitisation.

For more information on the conference, visit .

If you visit 17�Թ���, one of the first things you’ll notice is the great number of bee images throughout the city. Born in the Industrial Revolution, the “worker bee” symbol captured the city’s tireless spirit and its legacy as a buzzing hive of industry. Today, the symbol is more often associated with collective resilience and remembrance following the 17�Թ��� Arena attack on May 22 2017.

The bee became a of the “Mancunian spirit”, emerging almost instantly on murals, on bodies as tattoos and on public memorials. Over the last eight years, it has become a core part of 17�Թ���’s identity.

As part of my ongoing PhD research, I set out to understand why the bee is everywhere in 17�Թ��� and what it means to people. I interviewed 24 Mancunians who were living in the city at the time of the attack, including some who were directly affected.

Conducted in 2023, seven years after the attack, these interviews aimed to capture how the symbol’s meaning had evolved as the city continued to process and commemorate the event.

For many, the bee still stands as a symbol of resilience, a reminder of how the city came together in the face of tragedy. But for others, its presence throughout 17�Թ��� has become more of a burden than a comfort.

Appearing on buses, shop windows and public spaces, it serves as a constant and eerie reminder of the events and aftermath of the attack. Eight of my interviewees described these as memories of “trauma”. Over time, what once felt comforting has become more unsettling.

Fifteen of my interviewees expressed discomfort with how the bee has become more commercialised in the years since the attack. Some described feelings of “exploitation”.

Both independent businesses and large companies have embraced the symbol, integrating it into their branding in public spaces. Many sell bee-themed gifts and souvenirs, such as .

17�Թ��� city council has played a key role in this commercialisation, promoting the image through various initiatives, including the Bee Network transport system and the Bee Cup – a reusable launched in 2023.

In June 2017, shortly after the attack, the council moved to trademark several versions of the bee as an official city symbol. This was made public in March 2018, after the period for .

Initially, the council allowed people and businesses to use the symbol for free, but later introduced a . Now, anyone wishing to use the of the bee must apply for permission from the council, and commercial use comes with a £500 fee. Businesses that want to use the bee are also asked to donate to charity.

The council described the trademarking of the bee symbol as a way to protect its use and support local good causes, such as the , which helps fund community projects and youth opportunities across the city.

But some of my participants noted that this transformed the bee from something personal and meaningful to something more corporate. In their view, it is as if the city itself is commodifying the attack rather than honouring it.

This can be viewed as an element of “dark tourism”, which involves visiting places where tragedy has been memorialised or commercialised. this manifests not through visits to the attack site but through the bee symbol, which has been commodified in murals, merchandise and public spaces. Tourists buy into collective grief through consumption, turning remembrance into a marketable experience and the bee as a managed and profitable commodity.

Some 17�Թ��� Arena bombing survivors I spoke to feel that their personal grief has been repackaged into a public identity, one that does not necessarily reflect the complexity of their experiences.

The use of the bee in products and souvenirs raises questions about how the city commercialises its identity, especially when considering the layered histories that the symbol carries.

Uncomfortable history

For some, the discomfort around 17�Թ���’s bee goes even . Today, the bee symbolises resilience and unity, but it originally represented hard work during 17�Թ���’s industrial boom.

This era wasn’t just about progress — it also involved especially through cotton by enslaved people in the Americas. 17�Թ���’s role in the industrial revolution would have never been possible without slavery.

My participants pointed out this hidden history, noticing that these stories rarely appear in 17�Թ���’s public commemorations in the city. The bee’s visibility today reveals how cities tend to highlight positive histories, while uncomfortable truths .

A painted window in 17�Թ���’s Victoria station. Ashley Collar

Focusing solely on resilience risks creating a simplified version of 17�Թ���’s past. , overlooking how historical injustices, like the city’s links to the transatlantic slave trade, still shape their lives today.

This selective storytelling makes it harder for some communities to commemorate 17�Թ���’s identity. They can’t do so without acknowledging past legacies of slavery and the city’s history of division.

While some see the bee as a proud symbol of unity, others feel it erases their history. As the bee continues to dominate public spaces, 17�Թ��� faces an important challenge: making sure this symbol genuinely acknowledges the varied experiences and histories of all residents.

This might be through dedicated plaques or exhibits that explore some of these hidden histories, and the bee’s complex meaning. Only by confronting its past can the city ensure that commemoration includes everyone.

, PhD Candidate in Sociology at 17�Թ��� and Associate Lecturer in Criminology at MMU
This article is republished from under a Creative Commons license. Read the .

The research, funded by Forces in Mind Trust, was the first qualitative study with ex-Service personnel living with dementia in the community in the UK.

The study  found that having the dual identities of being someone with a dementia diagnosis, and also being ex-military, caused specific challenges in accessing and receiving appropriate support. The study highlighted that they are between two separate support systems, neither of which fully supports their needs, and between which communication can be poor.   

Ex-Service personnel living with dementia in their own homes are commonly referred to as ‘living in the community’, as opposed to living in a care home or other supported accommodation. Although ex-Service personnel have been shown to have similar rates of dementia to the general population¹, they often have distinct support needs, that require specific understanding of their identity as an ex-Service person.

Though support is available for ex-Service personnel living with dementia through community-based support groups, initiatives were described as frequently short-term, with very few support groups that covered the dual identities of both being an ex-Service person and someone living with dementia. This led to this support not addressing their distinct support needs.

Interviews found that some ex-Service personnel were more willing to engage with services designed  specifically for the Armed Forces community.

Ex-Service personnel living with dementia also voiced concerns that support provision was not well advertised saying that services were not “joined-up” making it difficult to access the correct support.

The qualitative study was based on in-depth interviews with 15 care providers in the North-West of England, as well as 11 ex-Service personnel living with dementia and their care partners as well as two policy and practice workshops with stakeholders.

Although the research was an exploratory study, it outlines several recommendations to improve the support landscape for ex-Service personnel living with dementia, as well as areas that need to be better understood.

• Improving identification of ex-Service personnel at appropriate screening points in health and social care can assist with signposting. If identification was made by Memory Assessment Teams (who usually conduct dementia diagnoses) ex-Service personnel could be directly signposted to support available for them.
• Promoting joined-up working would reduce barriers in to accessing appropriate support, for example by training staff and volunteers supporting ex-Service personnel with dementia training or by ensuring those in dementia services are aware of ex-Service personnel-specific services.

Dr Lydia Morris, Division of Psychology and Mental Health at the University of 17�Թ��� said: “Ex-Service personnel living with dementia in the community can be a group that falls through the cracks of support provision. We set out in this research to hear their lived experience for the first time in the UK. The dual identities of serving in the military and living with dementia create unique support needs that can make individuals feel like they have fallen between different support networks leading to confusion and poorer health outcomes.”

Michelle Alston, Chief Executive of Forces in Mind Trust said: “Ex-Service personnel living with dementia in the community can be a ‘hidden’ part of the Armed Forces community. This research allowed us to hear directly from those affected by dementia for the first time in research in the UK, and clearly outlines some of the barriers to them receiving support. We hope that this study can be translated to make more consistent and more accessible support for ex-Service personnel living with dementia."

The Awards highlight the extensive range of social responsibility initiatives across the University community and include categories such as environmental sustainability, alumni contribution, widening participation and equality, diversity and inclusion.

Over 130 entries were submitted this year with judges recognising 14 winners and 23 highly commended. Winners included a recruitment initiative providing meaningful employment opportunities for members of our local community; an initiative that aims to inspire underrepresented students to pursue a career in research; and a project addressing asthma diagnosis, improving access and patient care.

Winning student-led initiatives included projects ranging from a student-led initiative teaching children in Kenya about oral health, to a project promoting sustainable transport and healthy lifestyles through bicycle use.

In addition to the Making a Difference Awards, two University Medals for Social Responsibility were presented, one to a member of staff and one to an alumnus. The recipients were Lee Barlow for The Bright Idea project, a solar solution transforming campus energy and cutting Scope 1 and 2 emissions; and Charles Bakolo Mvula for a youth-led environmental movement initiative which is championing environmental sustainability in Malawi.

During the event a special Making a Difference Award was presented to the Tyndall Centre 17�Թ���. The Award recognises 25 years of the UK’s first interdisciplinary climate change research centre. The Tyndall Centre’s mission is to work across disciplines and academia to shape effective and evidence-based policy to create real world impact. 

Speaking at the Award ceremony Professor Duncan Ivison, President and Vice-Chancellor, said: “Tonight we have seen the extraordinary gift of expertise, care and commitment that has been given by our staff, students and donors to the communities that we serve. It has been inspiring to be part of these Awards and witness this work. I’d also like to say a huge thank you to all of the community groups and partners that work with us to make a difference.”

Dr Julian Skyrme, Executive Director of Social Responsibility and Civic Engagement, said: “We pride ourselves on being a pioneering institution for social responsibility, and these Awards provide an opportunity to recognise and celebrate the incredible work our staff, students, alumni, and partners do each year to enhance the wellbeing of society and the environment.”

Professor Nalin Thakkar, Vice-President for Social Responsibility, concluded: “The Making a Difference Awards are a true celebration of extraordinary individuals and teams and the spirit within our University; an inspiring reminder of how passion, dedication, and vision can drive meaningful change. As we shape our strategy for 2035, our award winners illuminate the path forward, showing us the remarkable potential we have to transform lives and communities, both locally and globally.”

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The new Fellows have been recognised for their remarkable contributions to advancing medical science, groundbreaking research discoveries and translating developments into benefits for patients and the wider public. Their work exemplifies the Academy’s mission to create an open and progressive research sector that improves health for everyone.

The expertise of Fellows elected spans a wide range of clinical and non-clinical disciplines, from infectious disease and stem cell biology to veterinary medicine and dementia research. They join an esteemed Fellowship of 1,450 researchers who are at the heart of the Academy’s work, which includes nurturing the next generation of scientists and shaping research and health policy in the UK and worldwide.

This year’s cohort reflects the Academy’s ongoing commitment to promoting equality, diversity and inclusion within its Fellowship. Among the new Fellows, 41% are women – matching last year’s intake. Black, Asian and minority ethnic representation has reached 20% as the Academy continues working on improving the diversity of its Fellowship.

Professor Abel joins the Fellowship following groundbreaking research on the effects of maternal condition and fetal environment on offspring outcomes, with a particular focus on children living with parental mental illness, who face multiple disadvantages. In this growing group of children at risk, her work highlights when, and in which children, interventions are most likely to improve outcomes. This allows policy makers and service planners to optimise the value of limited resources for a growing population in need.

She said: “Nearly half of UK children will experience a parent with significant mental illness by the age of 16 and, as a result, will have worse physical and mental health, lower educational attainment and reduced quality of life. We can now harness the UK’s fantastic data resources and, along with novel imaging and clinical prediction models, support families most in need in this growing at-risk group. I am truly delighted to be elected as a Fellow of the Academy of Medical Sciences – a uniquely effective platform through which I can continue to advocate for this vulnerable and hidden group of children.”

Professor Tony Day, a member of the 17�Թ��� Cell-Matrix Centre, is a world leader on glycosaminoglycan-protein interactions, which he has explored in the context of both physiological and inflammatory processes. For example, Tony has pioneered research on proteins that bind the polysaccharide hyaluronan, a central component of the mammalian extracellular matrix. Tony’s work has provided insights into the molecular basis of cumulus expansion, a process essential for ovulation, including the biochemistry of how the TSG-6 protein mediates the covalent modification of hyaluronan to form ‘HC•HA’ complexes. Formation of these complexes also represents a novel pathway in inflammation, with important implications for ongoing work by Tony and colleagues on virus/parasite-induced lung pathologies.

Underpinned by his 30 years of research on TSG-6, Tony has developed a biological drug, ‘Link_TSG6’, that has wide applicability for inflammatory and tissue-degenerative diseases. To take this forward, he co-founded Link Biologics, a University of 17�Թ��� spin out company that is developing treatments for dry eye disease and osteoarthritis, conditions that each affect ~350 of million individuals worldwide.

Professor Day said: "I am absolutely delighted to be elected as a Fellow of the Academy of Medical Sciences and get recognition for my team’s research in the fields of matrix and glycosaminoglycan biology”.

Professor Matt Sutton is an internationally-renowned health economist at the forefront of providing real-time, economic evidence to inform critical health policy choices. He has produced a body of highly-influential and practical work on payment methods and financial incentives in health care. He shows how these can improve the quality of care given to patients, increase system efficiency and reduce inequalities, but may also have unintended consequences.

He has demonstrated socioeconomic and ethnic inequalities are pervasive even in a national universal coverage system like the NHS and has helped improve fairness in the health sector across the United Kingdom by leading multiple reviews of the formulae used to direct additional resources to the areas of highest need. 

Professor Sutton works closely with policy advisors and analysts in national organisations to ensure research reaches decision-makers. At critical points in policymaking, he produced evidence to challenge the presumption that the “weekend effect” in hospital mortality was caused by inadequate staffing, generated real-time findings on the effectiveness of the COVID vaccination programme, and demonstrated the effectiveness of the national diabetes prevention programme.

He said:  “Being elected a Fellow is great honour as it is a one of the highest recognitions of excellence in the field of biomedical and health research in the UK.  It will be  a crucial aid in contributing to  national health policy discussions and provide  a platform to influence decisions that shape healthcare.”

Professor Andrew Morris CBE FRSE PMedSci, President of the Academy of Medical Sciences, said: “It is a privilege to welcome these 54 exceptional scientists to our Fellowship. Each new Fellow brings unique expertise and perspective to addressing the most significant health challenges facing society.

“The breadth of disciplines represented in this year’s cohort – from mental health and infectious disease to cancer biology and respiratory medicine – reflects the rich diversity of medical science today. Their election comes at a crucial time when scientific excellence and collaboration across disciplines are essential for addressing global health challenges both now and in the future. We look forward to working with them to advance biomedical research and create an environment where the best science can flourish for the benefit of people everywhere.”

The new Fellows will be formally admitted to the Academy at a ceremony on Wednesday 9 July 2025.

The Ideas With Impact Prize, which is supported by philanthropic donors to the University, aims to award £300,000 in its first funding round this summer. 

Scaling up support for founders 

Delivered by Unit M and the Innovation Factory, Ideas With Impact Prizes will provide individual awards of £100,000, £50,000, and £20,000 to entrepreneurs at the early stages of their founder journey. These awards will empower projects that address pressing local and global challenges, ensure 17�Թ���’s best technologies move out into the world more quickly, and create tangible economic growth.  

In addition to financial support, winners will receive access to experienced mentors, networking opportunities, and guidance in translating research into viable business ventures. 

Donors at the heart of our innovation ecosystem 

The Prize is the latest development in the University’s Ideas With Impact partners’ programme, which has previously provided £400,000 to early-stage research spinouts. Successful projects include the development of a home-testing kit for the early detection of lung cancer, as well as Plant Organelle Technologies – a new spinout developing targeted techniques to tackle drought and herbicide resistance in plants. By reaching a wider range of founders, the Prize launch will maximise the impact of gifts to the programme. 

Donors have already made a great difference to the University’s innovation ecosystem, and will play a vital role as we scale up our ambition to become Europe’s leading innovation university. Ideas With Impact is more than a funding initiative. It's a celebration of the partnership between philanthropists and the University in driving innovation-led growth. 

A call to budding founders and innovators 

Got a great idea with commercial promise? Applications are now open!   

Ideas With Impact is open to any student, staff member, or recent graduate (within three years of graduation) of 17�Թ���, who have the ambition to turn their research and ideas into enterprises that change lives. Key dates below: 

• 20 June 2025: Applications close. 
• 27 June 2025: Finalist announcement. 
• 14 July 2025: Finalist Pitching Competition and networking event. 

Learn more about the Ideas With Impact Prizes and the application process on the University’s  

Philanthropic Support 

Interested in supporting brilliant future founders and ensuring entrepreneurship for all? We’d love to explore opportunities with you. 

Contact Olympia Kennard to begin a conversation: Olympia.Kennard@manchester.ac.uk. 

Our innovation ecosystem 

• Read more about Unit M here:  
• Read more about the Innovation Factory here:   
• Read more about the Innovation Academy here:  

The PACE programme marks a major shift in how UK policing engages with science and evidence. The initiative will create a collaborative, nationwide research infrastructure that reflects policing’s Areas of Research Interest (ARIs) - from public protection to digital transformation. Each centre will act as a gateway to independent academic advice, helping forces to navigate complex issues and adopt effective, ethical strategies that serve diverse communities.

As the UK faces fast-changing demands on its police services, the launch of the PACE network signals a long-term commitment to smarter, safer, and more responsive policing - backed by the best that British academia has to offer. 

“This is about making sure policing decisions are grounded in the best available knowledge,” said Chief Constable Gavin Stephens, NPCC Chair. “It strengthens our commitment to evidence-based practice and shows our determination to be more transparent, accountable and effective.”

Stian Westlake, Executive Chair of the Economic and Social Research Council (ESRC), said: “The Policing Academic Centres of Excellence will forge closer relationships between police forces and researchers, providing the police with data and evidence to make the justice system work better.

“By bringing experts in policing practice together with social scientists and data scientists across the country, the centres will provide knowledge and insights to drive service improvement. These centres of excellence demonstrate our commitment to reducing crime and making Britain a safer place.”

Inclusion of families is a key part of guidance to universities on conducting such reviews but the study found that in most cases it did not happen. Some families described feeling the university was defensive and reluctant to answer important and painful questions. 

The study found the commitment to suicide prevention in universities is strong. However, it recommends reviews are more responsive to families and proposes a “duty of candour” should be developed and adopted by the higher education sector. 

Most of the serious incident reviews identified potential stressors and experiences that could have contributed to suicide risk. Mental ill-health and academic problems including exam stresses were the most common factors. Around three-quarters of students had been in contact with university support services. Many had experienced adverse life events, including relationship problems, problems with housing, family relationships, their peers, or finance. 

The serious incident reports showed that 13% of the students, five female and five male, were reported to have been victims of violence, including sexual or physical assault, harassment or threats of violence. In three, the gender of the student was not reported. 

Over two-thirds (53, 67%) of the 79 reports of suspected suicide detailed how the university responded to the death, known as postvention.

Postvention to fellow students was documented in 32 (41%) of the 79 serious incident reports but just 7 (9%) said the student’s family received support. The figure was 14 (18%) for staff impacted by the death.

A total of 107 students at 73 English universities were suspected to have lost their lives to suicide in the 2023/2024 academic year. 62 incidents of non-fatal self-harm were also reported in the same period. Of the 169 cases, serious incident reports were submitted for 104 (62%) of them. And of the 104 reports, 79 (74%) were for suspected suicide and 25 (40%) for incidents of non-fatal self-harm.

, Director of the into Suicide and Safety in Mental Health at 17�Թ���, said: “A single life lost to suicide is an immeasurable tragedy. The main aim of this national review is to improve learning from these tragic incidents to help prevent future deaths. We found an excellent response from universities to this national review and, on such a sensitive issue, this is a welcome sign for prevention.

“However, the families we spoke to provided moving accounts of feeling excluded from the process of finding out what happened to their loved ones, and some had a perception the university was evasive and reluctant to answer important and painful questions.

“That is why input from bereaved families should be a key part of the serious incident investigation process, and their questions should be answered as far as possible.

“We suggest a version of the duty of candour should be introduced to the HE sector. This would have the aim of, ensuring openness and transparency with families after a suspected suicide. This should be developed and shaped by the sector itself to ensure it is appropriate to the HE setting.”

from 17�Թ��� said: “Mental-ill health was frequently identified in the serious incident reports we examined, sometimes there were clear indications of risk through mental illness or self-harm, but other reports identified students who were experiencing less severe problems with mental well-being. We suggest mental health awareness and suicide prevention training should be available for all staff in student-facing roles, and include recognising and responding to risk and neurodiversity.

“And students who are struggling academically should be recognised as potentially at risk, with enhanced support being offered at key points in the academic calendar. Access to mental health and other support should also be reviewed, particularly for those at additional risk, such as those who have experienced violence or other adverse life events.”

• The study is published on the  DfE

Officially known as Leader in Openness, the award, which needs to be renewed every three years, is given by Understanding Animal Research, a key body which promotes understanding of the humane use of animals in medical, veterinary, scientific and environmental research in the UK.

'Leaders in Openness' status - first awarded to 17�Թ��� six years ago - recognises organisations who dedicate significant resources to embedding best practice throughout their organisation, ensuring that transparency is not just an aspiration but a reality at every level.

The University's Biological Services Facility has long been a leading university for openness about the work it carries out with animals - which includes mice, rats, frogs, fish and sheep.

17�Թ��� was one of the original signatures of the Concordat on Openness on Animal Research, a set of four commitments to help organisations which carry out animal research to communicate openly about their work and the reasons why they do it.

 Dr Maria Kamper Biological Services Facility Director at 17�Թ��� said: "The University's commitment to the Concordat on Openness in Animal Research drives our transparency in animal studies. 

"With just a few clicks, the public can access details about our research methods, animal species, numbers, and ethical frameworks. We offer virtual tours, participate in science fairs, and host various public events. School groups, journalists, and community members also regularly visit our facilities. 

"This recognition of the efforts of the BSF staff is gratifying, and we enthusiastically pledge to continue advancing this important transparency agenda."

It has been shown that greater openness on how and why animals are used enables the public to consider both the potential benefits and the ethical considerations, fostering informed discussion and trust.

Hannah Hobson, Head of Communications and Engagement at Understanding Animal Research said: "Each year, the Concordat recognises institutions that consistently meet the highest standards for openness and transparency in their animal research communications. These organisations excel in internal communications, public-facing websites, social media, media engagement, and public outreach, setting a benchmark for the sector and leading by example.

"For 2025–2028, a select group of research organisations has once again demonstrated outstanding commitment in all these areas, earning the 'Leaders in Openness' title for three years. This recognition reflects the energy, thoughtfulness, and courage they show in making information about animal research accessible and understandable to the public on a subject that is often complex and misunderstood."

• For more details about leader in openness, visit the website
• If you have any questions about animal research at 17�Թ���, email animal research communications lead Mike Addelman and Communications and 3Rs manager at the BSF Dr Jo Stanley  at animal.research@manchester.ac.uk

“It’s rare to see a project where everyone - researchers, artists, students, and audiences - walks away changed,” says Helbig. “We’re not just making theatre. We’re co-creating new ways of thinking, feeling, and connecting across difference.”

Each play is infused with the distinctive voice of its creators - from poetic monologues to ensemble movement, to satire and sensory storytelling. Following the performance, audience members are invited to stay for a candid conversation with the creators, discussing the themes, the process, and what it means to tell stories across cultures.

In a time of global complexity and cultural tension, it offers a rare chance to pause, reflect and connect. It celebrates the diversity of lived experience and invites audiences to engage directly with the kinds of questions anthropology is uniquely positioned to ask. 

Tickets for the event can be purchased at . 

Tiny Human Dramas is part of an expanding vision - the team is currently developing a short documentary film about the creative process and exploring opportunities to take the project to national festivals, including the Edinburgh Fringe and the ESRC Festival of Social Science.

As the UK strives to reach Net Zero emissions by 2050, secure and permanent geological storage of CO₂ is essential to avoid the worst-case consequences of climate change.

Storage in deep geological formations such as depleted oil and gas reservoirs and saline aquifers offers a promising solution. However, these underground environments host diverse microbial ecosystems, and their response to CO₂ injection remains poorly understood.

This knowledge gap poses a potential risk to long-term CO₂ storage integrity. While some microbial responses may be beneficial and enhance mineralogical or biological CO₂ sequestration, others could be unfavourable, leading to methane production, corrosion of infrastructure, or loss of injectivity.

The new flagship project with 17�Թ��� and Equinor - global leaders in geological CO₂ storage - will investigate how subsurface microbial communities respond to CO₂ injection and storage, highlighting both the potential risks and opportunities posed by these microbes.

Principal Investigator, Prof Sophie Nixon, BBSRC David Phillips and Dame Kathleen Ollerenshaw Fellow at 17�Թ���, said: "Over the past 20 years, scientists have tested storing CO₂ underground in real-world conditions, but we still know little about how this affects native and introduced microbes living deep below the surface.

"Previous studies have shown that injecting CO₂ underground actively changes microbial communities. In some cases, microbes initially decline but later recover, potentially influencing the fate of injected CO₂ in geological storage scenarios. However, these studies predate the advent of large-scale metagenomic sequencing approaches. A deep understanding of who is there, what they can do and how they respond to CO₂ storage is crucial for ensuring the long-term success of carbon capture and storage."

The two-year project will collect samples from saline aquifer and oil producing sites to study how microbes living deep underground respond to high concentrations of CO₂ by combining geochemistry, gas isotope analysis, metagenomic and bioinformatic approaches.

Project Co-Investigator, Dr Rebecca Tyne, a Dame Kathleen Ollerenshaw Fellow at 17�Թ���, said: “To date, Carbon Capture and Storage research has focused on the physiochemical behaviour of CO₂, yet there has been little consideration of the subsurface microbial impact on CO₂ storage. However, the impact of microbial processes can be significant. For instance, my research has shown that methanogenesis may modify the fluid composition and the fluid dynamics within the storage reservoir.”

Currently, the North Sea Transition Authority requires all carbon capture and storage sites to have a comprehensive ‘Measurement, Monitoring and Verification’ strategy, but microbial monitoring is not yet included in these frameworks. The project’s findings will be shared with industry stakeholders and published in leading scientific journals, helping to close this critical gap and shape future operational activities.

Project Lead, Leanne Walker, Research Associate in Subsurface Microbiology at 17�Թ���, said: "This project will help us understand the underground microbial communities affected by CO₂ storage—how they respond, the potential risks and benefits, and the indicators that reveal these changes.

"Our findings will provide vital insights for assessing microbiological risks at both planned and active CCS sites, ensuring safer and more effective long-term CO₂ storage”.

Building upon his 2024 book, , the unsettling history of role-playing in ‘constructed situations’ is explored through his commentary on the performative dynamic of the experiment and its wider societal implications. Students from the School of the Arts, Languages & Cultures also feature in the reenactments shown in the series. 

To mark the UK premiere, the , in partnership with , will be hosting an in-conversation event on Wednesday 4 June titled ‘’.&�Բ�����;

Professor Stephen Scott-Bottoms will be joined by from the , who is also among the expert commentators featured in the series, alongside , Director of the docuseries. An internationally recognised expert on social identity, collective behaviour, intergroup conflict, and leadership influence, Professor Stephen Reicher co-led the BBC’s partial reconstruction of the Stanford Prison study,  

The event will feature behind-the-scenes insights into the making of the series, a discussion on the enduring relevance of the Stanford study and a live audience Q&A. It is open to the public and promises a compelling dialogue on truth, myth, and morality in psychological research.

Register for

The documentary series, The Stanford Prison Experiment: Unlocking the Truth, is set to air on .

The treaty suspension reflects a growing regional trend: South Asian countries are increasingly treating water as a strategic asset rather than a shared resource amid rising mistrust, climate stress and geopolitical competition.

The region is home to nearly a quarter of the global population, and relies on huge transboundary rivers fed by Himalayan glaciers – the so-called of freshwater reserves. A breakdown in water diplomacy could trigger environmental collapse, humanitarian crises and geopolitical instability. The weaponisation of water must be urgently addressed as a global climate justice issue.

A flashpoint occurred in August 2024 when devastating floods affected in Bangladesh. Some Bangladeshi officials accused India of releasing excess water from a large dam upstream without warning. India , citing extreme rainfall and standard dam operations. Nevertheless, the incident reignited longstanding tensions between the two countries.

Complicating matters further is China recently approving the construction of the on the Yarlung Tsangpo river in Tibet, which becomes the Brahmaputra in India. This massive project has about China’s ability to exert control upstream, and the ecological risks for India and Bangladesh downstream.

China hasn’t signed formal water-sharing agreements with its neighbours, but its growing presence in regional water infrastructure signals a dramatic shift in south and east Asian hydro-politics.

Climate change is making things worse

Recent climatic trends are making transboundary rivers an increasing focus of geopolitical friction. These trends include accelerated , , and intensifying extreme weather.

While melting glaciers will temporarily boost the flow of rivers, the long-term prognosis is bleak. If emissions and warming trends continue, many glacier-fed rivers – including the Indus, Ganges and Brahmaputra – could see by the end of the century. This will directly affect hundreds of millions of people who depend on them.

The crisis is being intensified by changes in the Himalayas. The region is warming faster than the global average, with a shift from snowfall to rainfall that disrupts the timing and volume of water that flows down from the mountains to the fields and cities below.

At the same time, has pushed South Asia’s reserves of underground water toward collapse, threatening both food and water security.

A dangerous precedent

A collapse or suspension of the Indus Waters Treaty could set a dangerous precedent. Importantly, the threat is less about India cutting off water flows – an unlikely and technically challenging act – and more about the erosion of trust, transparency and data sharing.

One of the treaty’s most valuable features has been the routine sharing of data on things like water levels, river flow and dam operations. Pakistan needs this data to forecast floods and droughts, plan its irrigation, generate hydropower effectively and manage its drinking water, yet India is indicating it will no longer honour these obligations.

But India’s strained water relations are not limited to Pakistan. Bangladesh and Nepal have often felt sidelined or pressured in negotiations, and India’s indication that it may reconsider longstanding treaties raises concerns in both countries.

This is especially the case as the Ganges Water Treaty nears its 2026 expiration: the vast Ganges river flows through India and irrigates much of Bangladesh – and the treaty guarantees Bangladesh a minimum river flow.

Other key agreements, such as the and with Nepal, and the with Bangladesh, remain largely unimplemented, breeding mistrust. These failures undermine confidence in regional water diplomacy and cast doubt on India’s commitment to equitable cooperation.

None of this is helped by India, Pakistan and Bangladesh all continuing to rely on outdated irrigation methods that mean they use more water than necessary. As climate change intensifies floods, droughts and glacial melt, there is an urgent need to reform existing water treaties to reflect present-day climate, hydrological and geopolitical realities.

The Indus Waters Treaty, negotiated in the 1960s before the emergence of modern climate science, no longer accounts for these transformations. Indeed, most water treaties in the region remain rooted in technocratic, engineering-centric frameworks which fail to address extreme climate variability and its cascading impacts.

The upcoming expiration of the Ganges Water Treaty, and the pending negotiation of other basin agreements, present a critical opportunity to rethink water governance in South Asia.

Though the Indus flows through India before Pakistan, in other basins, India is downstream. This is the case with the Brahmaputra, where it demands upstream cooperation from China.

Undermining the Indus treaty could weaken India’s own position in future negotiations and strain its relations with Nepal and Bangladesh, while giving China more influence in South Asian hydro-politics. China is already expanding its footprint by offering billions in loans to Bangladesh and strengthening ties with Nepal, particularly around water infrastructure.

Weaponising water is a perilous strategy that may backfire. The weakening of water diplomacy in South Asia is not just a regional threat; it endangers global climate security.

In the face of escalating climate change impacts and recurring disasters, updating transboundary agreements like the Indus Waters Treaty, Ganga Water Treaty, and Kosi and Teesta accords is no longer optional – it is an urgent necessity with enormous consequences.

, Leverhulme Early Career Fellow, Geography,
This article is republished from under a Creative Commons license. Read the .

Taking place in 17�Թ��� - the birthplace of KTP - the event will mark the pinnacle of national 50^th year celebrations, bringing together the KTP community for a programme of guest speakers, workshops and seminars. 

Since their launch in 1975, the UK Government has funded over 14,000 groundbreaking KTPs, uniting top businesses with researchers and graduates to solve real-world challenges, adding billions to the UK economy.  From 2010 to 2020 alone, Innovate UK invested £200m in 2,000 projects, adding £2.3bn to the UK economy. 

The Innovate UK KTP Awards will showcase this year’s finalists, alongside the KTP Golden Awards - these special honours will highlight legacy projects, partnerships and people that have profoundly shaped the UK economically, socially and environmentally over the last five decades. Registration for the conference and awards is now open, with early bird pricing available until Monday 30 June 2025. 

Minister of State for Science, Research and Innovation, Lord Vallance, said: “Knowledge Transfer Partnerships have long supported collaboration between our renowned universities, UK innovators and thriving businesses – from helping household brands to produce their goods more efficiently through to unleashing new discoveries that improve lives.  

“They also demonstrate the benefit of public investment, with ambitious, Innovate-UK-backed projects across the country having added billions of pounds to our economy in the previous decade alone. I look forward to these partnerships supporting the next generation of cutting-edge innovations.”  

KTPs are a UK-wide programme designed to foster innovation by linking businesses with academic institutions. With funding and support provided by Innovate UK, the scheme enables companies to access cutting-edge research and specialist knowledge to solve strategic challenges, develop new products and enhance their competitive edge. Greater 17�Թ��� was part of the original pilot of the Knowledge Transfer Partnerships scheme when it launched in 1975.  

In a joint statement, the Vice-Chancellors of the three host universities - the University of Salford, 17�Թ��� Metropolitan University and 17�Թ��� - said: “Together, we are proud to be co-hosting the KTP 2025 Conference and Awards in the birthplace of Knowledge Transfer Partnerships. For 50 years, KTPs have exemplified the power of collaboration between universities and industry - driving innovation, supporting economic growth and tackling real-world challenges.  

“This milestone celebration is not only a tribute to the enduring impact of the programme, but also a springboard for shaping the next era of research-driven partnerships that benefit society locally, nationally and globally.” 

Richard Lamb, KTP Programme Manager at Innovate UK, said: “Celebrating 50 years of the Knowledge Transfer Partnerships programme offers a valuable opportunity to recognise its enduring impact on UK innovation and economic resilience. By bridging academia and industry, KTP has extended vital opportunities to businesses and academic partners across the UK, reaching beyond London and the Southeast to drive innovation in fields ranging from STEM to the creative industries and pioneering areas like AI and quantum technology.  

“This collaborative model has not only boosted productivity and growth but has empowered organisations of all sizes to innovate and thrive on a local and national scale. This 50th anniversary is the perfect occasion to reflect on the impressive impact achieved through the programme and its lasting legacy.”  

The KTP 2025 Conference is aimed at KTP associates, practitioners, academics and funders, whilst the Awards will bring together business, associate, academic and practitioner teams behind the UK’s most transformative projects. 

Find out more about the conference and reserve your place:  

New analysis from Health Equity North, Newcastle University, and the University of 17�Թ��� has shown that availability of community pharmacy services in England has reduced, particularly in deprived areas.

Researchers investigated how access to community pharmacies changed from 2014 to 2023, examining relationships between pharmacy availability and factors such as how urban the area is, and socioeconomic deprivation.

In England, more than 90% of people live within a 20-minute walk of a community pharmacy. However, overall availability of pharmacies has decreased with the number dropping from 1.6 pharmacies per 10,000 people to 1.5. The most deprived areas were 65% more likely to lose a pharmacy compared to the least deprived areas.

Pharmacies are an important part of the healthcare system and are well placed to reach those most in need. They deliver a range of public health and clinical services, such as smoking cessation advice and support, emergency hormonal contraception, hypertension screening and ‘flu’ vaccination programmes.

Recent funding cuts and closures of community pharmacies prompted health inequalities researchers to explore whether the ‘positive pharmacy care law’ – which means people in more deprived areas have better access to pharmacies - is still in operation, and the implications of this on commissioning of future services.

It found that the positive pharmacy care law remains in place but has eroded over time. Pharmacy availability is decreasing, especially in poorer areas, meaning more people must rely on each remaining pharmacy.

The research team says that due to the nature to the NHS Community Pharmacy Contractual Framework in England and the tiered levels of services, “there is potential that there will be less capacity to provide the additional enhanced clinical services for community pharmacies located in the most deprived areas”.

The study showed:

• In 2014, the most deprived areas had 2.28 pharmacies per 10,000 people compared to 1.37 per 10,000 people in the least deprived areas; by 2023, this dropped to 2.01 and 1.33 per 10,000 people, respectively.
• The decline in pharmacy availability per 10,000 people was most severe in the most deprived areas (-0.27 per 10,000 people or an 11.8% reduction between 2014 and 2023)
• Urban areas experienced a significant decline in pharmacy availability - an 8.2% reduction (from 1.81 to 1.66 pharmacies per 10,000 people) between 2014 and 2023.

The academics behind the analysis say reinvestment in the community pharmacy network will help address challenges within the sector and reduce inequalities in access to health care.

Lead author Eman Zied Abozied, Research Associate at Newcastle University, said: “Pharmacies are one of the only healthcare options available on the high street where people can be seen without an appointment. They play an important role in helping people access the care they need, especially in the most disadvantaged areas where there might be fewer GPs. Funding cuts across the sector have seen many community pharmacies close, which could fuel inequalities in healthcare access.

“While it is encouraging that our analysis shows that most people still live close to a pharmacy, the reduction in the number of community pharmacies is a cause for concern. Pharmacies are serving a higher number of people, with the biggest decline in availability in communities that have the greatest health needs, leading to immense pressure on services and staff. Pharmacies in the most disadvantaged areas may not be able to offer the full range of clinical services due to funding cuts and staffing pressures.

“If community pharmacies are required to deliver more clinical services to support other primary care organisations, it is important that they have the appropriate funding to be able to achieve this.”

Dr Luke Munford, Health Equity North Academic Co-Director and Senior Lecturer in Health Economics at 17�Թ���, said: “There needs to be more investment in community pharmacies if they are to effectively deliver the vital public health services they provide to people across England. Our study shows that more pressure is being placed on pharmacies with this being felt more keenly in deprived communities where health outcomes tend to be worse. 

“The implications of inaction could see less capacity to provide much need services to those most in need and further widening of existing health inequalities.” 

The study has been published in BMJ Open. Read the full paper - "The Positive Pharmacy Care Law Revisited: an area-level analysis of the relationship between community pharmacy distribution, urbanity and deprivation in England"

The  groundbreaking research, led by Dr Matthew J. Kibble, used a state-of-the-art 3D printing technique called bioprinting to replicate the complex structure and environment of human spinal discs. 

In a study published in the journal today, they reveal tissue stiffness and oxygen levels significantly impact the production of vital biological materials, including collagen and hyaluronic acid, by human disc cells. 

The insights could ultimately lead to new treatments for back pain, a condition affecting hundreds of millions of people across the world. 

Bioprinting is a cutting-edge technique that uses living cells and biological materials to create complex 3D structures that accurately mimic the structure of human organs. 

The new bioprinted discs will allow scientists to study how different conditions affect disc cell behaviour and contribute to tissue degeneration and back pain.

Most bioprinters work in a similar way to plastic 3D printers, extruding material through a nozzle under pressure to build structures.

However, rather than printing plastic, bioprinters use cells and gel-like inks made from cell-friendly materials such as collagen, cellulose or gelatin.

The scientists prepared the cells and materials needed for bioprinting and designed a digital model of a human spinal disc. For this study, the bioprinted discs were made from gels containing collagen combined with alginate, a protein derived from seaweed.

They used state-of-the-art 3D bioprinters capable of depositing multiple types of cells and materials, layer-by-layer, to create sophisticated models where the different biological, chemical, and mechanical characteristics of the human disc could be modelled.

The bioprinted tissues were then stored in controlled conditions so they could grow, mature, and develop their biological functions.

Dr Stephen M. Richardson, from 17�Թ���, corresponding author of the study said: “This work represents a step towards the automated creation of realistic whole organ models and brings us closer to understanding the root causes of disc degeneration.”

“Our findings provide important insights into the factors driving disc degeneration and pave the way for the development of more effective regenerative therapies, for example through incorporation of stem cells.”

Bioprinting has been used to fabricate models of different tissues including skin, brain, nerve and heart, kidney and tumour.

However, fully functional tissue engineered organs are still  decades away; current models are mostly used for investigating biological processes in the lab but may act as replacements for lab animals.

As part of his PhD research at 17�Թ���, Dr Kibble developed the bioprinted discs to explore the impact of tissue stiffness on the two cell types that inhabit different parts of the adult spinal discs:  nucleus pulposus and annulus fibrosus cells.

In future disc models the scientists plan to incorporate cells found in healthy, young developing discs, alongside stem cells or gene-edited cells to create even more advanced models of health and disease. This will enable them to understand how healthy tissue is formed and whether stem cells can be used to produce healthy tissue and treat back pain.

Dr Kibble said: “Over 600 million people worldwide suffer from lower back pain. Our bioprinted intervertebral disc models are an exciting opportunity to inform better regenerative therapies.

Our research has shown that tissue stiffness and oxygen levels have a significant impact the production of vital biological materials.

There have been many attempts to engineer discs so that we can understand their biology and develop models for testing different therapies or transplanting them into animals. But as well as being very difficult to do, this is also extremely time consuming.

Our work allows us to produce biologically functional disc models at scale and will allow us to make desperately needed advances in our understanding  of disc disease.”

The study was funded by the UKRI EPSRC/MRC Centre for Doctoral Training in Regenerative Medicine, the Wellcome Institutional Strategic Support Fund, and the Medical Research Council.

The authors also acknowledge the support of the national Henry Royce Institute EPSRC grants and the Bioprinting Technology Platform.

A video of the bioprinted in action is available, as are images of the bioprinted discs, and graphics.

The paper,  Suspension bioprinted whole intervertebral disc analogues enable regional stiffness- and hypoxia-regulated matrix secretion by primary human nucleus pulposus and annulus fibrosus cells is published in Acta Biomaterialia and is available.

17�Թ��� is globally renowned for its pioneering research, outstanding teaching and learning, and commitment to social responsibility. We are a truly international university – ranking in the top 50 in a range of global rankings – with a diverse community of more than 44,000 students, 12,000 staff and 550,000 alumni from 190 countries.  Sign up for our e-news to hear first-hand about our international partnerships and activities across the globe. 

Less climate mitigation will increase the spread of fungal pathogens in certain areas, putting more people at risk.

• Novel projections show that in 15 years, if we rely on fossil fuels instead of clean power (scenario of *), we are likely to see the significant spread of certain fungal pathogens in Europe
• Under this scenario, the spread of Aspergillus flavus, for example, could increase by about 16%, putting 1 million more people at risk of infection in Europe. Infections affect the respiratory system, and this fungus infects a broad range of agricultural crops
• The predictions also show that the spread of another fungus, Aspergillus fumigatus, could increase by 77.5% and potentially expose 9 million people in Europe
• This is a concerning trend due to a rise in antifungal resistance and a severe lack of diagnostics and treatment options for fungal infections

In a new study, published on  and funded by , the effects of rising temperatures on infection-causing fungi have been mapped under different climate change mitigation scenarios until the year 2100. Using climate modelling and forecasts, at the University of 17�Թ��� and colleagues have mapped how the global distributions of three fungal pathogens (Aspergillus flavus, Aspergillus fumigatus and Aspergillus niger) could be expected to change as a result.

The rise of pathogenic fungi is a real concern and is being driven by climate change. Fungi are incredibly adaptable organisms, with large, malleable genomes that allow them to colonize new geographies and survive as their environment changes.

Dr. Norman van Rhijn said: “Changes in environmental factors, such as humidity and extreme weather events, will change habitats and drive fungal adaptation and spread.

“We’ve already seen the emergence of the fungus Candida auris due to rising temperatures, but, until now, we had little information of how other fungi might respond to this change in the environment.  Fungi are relatively under researched compared to viruses and parasites, but these maps show that fungal pathogens will likely impact most areas of the world in the future. Raising awareness and developing effective interventions for fungal pathogens will be essential to mitigate the consequences of this.”

The maps show that in a fossil fuel dependent economy, as outlined in the IPCC scenario of , the climate will change to become suitable for fungal pathogens to spread to new geographies, with a marked increase in Europe.

The spread of Aspergillus flavus could increase by about 16%, putting 1 million more people at risk of infection from this deadly fungal pathogen in Europe. This fungus is known to cause severe infections and is resistant to many antifungals available.

This is an especially concerning trend as many fungal infections have high mortality rates, partly because of the lack of diagnostics, vaccines and treatment options as well as a lack of awareness of fungal infections. Additionally, as fungi are more similar to humans than other pathogens, developing anti-fungal treatments without toxic side effects is challenging.

The predictions also show that the spread of Aspergillus fumigatus could increase by 77.5% and potentially expose 9 million people in Europe. This is one of the most common fungal pathogens responsible for life-threatening infections in humans and affects the lungs.

Whilst the rise in global temperatures will increase the spread of fungi in Europe, temperatures in Africa could become so high that some fungi will not be able to survive on the continent. Fungi are an essential component to a functioning ecosystem, decomposing plant and animal matter to reintroduce nutrients into the soil. They also contribute to the carbon cycle which regulates the global climate and temperatures.  

Antifungal resistance is also being driven by the use of fungicides in agriculture, which are used to protect crops and support food production. The researchers also looked at the how the changing environment impacts our use of fungicides.

Viv Goosens, Research Manager at Wellcome said: “Fungal pathogens pose a serious threat to human health by causing infections and disrupting food systems. Climate change will make these risks worse. To address these challenges, we must fill important research gaps. By using models and maps to track the spread of fungi, we can better direct resources and prepare for the future." 

Fungal infections are transmitted through fungal spores in the air we breathe. People with weakened immune systems, co-morbidities and other risk factors are most vulnerable to infections, although fungi could adapt to become more pathogenic due to rising temperatures and could result in more infections in healthy people.

Despite this mounting threat, fungal infections receive little attention or resources. Less than 10% of an estimated 1.5 to 3.8 million species have been described, and a tiny fraction has had their genome sequenced. Wellcome is awarding over £50mn in funding towards fungal research over the next year. 

The study has been published on preprint platform Research Square, available here

It is the first time course providers have been subject to formal quality assurance by the regulator, which took on the responsibility of regulating PAs and Anaesthesia Associates (AAs) , of which overseeing and approving training courses is a key component, in December last year. 

PAs are healthcare professionals who work under the supervision of a senior doctor, such as a hospital consultant or a GP. 

Once they have completed two years of postgraduate training, they perform different clinical duties including taking medical histories, carrying out physical examinations, and developing and managing treatment plans. 

However, they are unable to prescribe medication or request ionising radiation, such as a chest X-ray or a CT scan.

Professor Tony Heagerty, Head of the School of Medical Sciences, said: “By handling routine care, follow-ups, and minor procedures, physician associates can improve workflow and reduce waiting times, as well as give doctors the time to focus on more complex cases.

“We are delighted to receive formal approval by the General Medical Council to teach physician associates to support this valuable addition to the NHS.”

In addition, three Anaesthesia Associate (AA) courses also received approval by the GMC.

Professor Colin Melville, the GMC’s Medical Director and Director of Education and Standards, said: “This is an important milestone in the regulation of PAs and AAs and will provide assurance, now and in the future, that those who qualify in these roles have the appropriate skills and knowledge that patients rightly expect and deserve.

“As a regulator, patient safety is paramount, and we have a robust quality assurance process for PA and AA courses, as we do for medical schools. We have been engaging with course providers for several years already, and we only grant approval where they meet our high standards.”

From richer biodiversity and benefits for pollinators, to carbon storage in soils, while balancing hay yields for grazing livestock, the study published in by researchers at 17�Թ��� and Lancaster University, in collaboration with the Universities of Yale and Bergen, shows that using combinations of different restoration techniques can markedly enhance the restoration of grasslands.

Given many current grassland recovery projects typically only use one type of technique, or ‘intervention’, in attempts to deliver ecological benefits, the scientists behind the study hope their findings can help boost grassland restoration initiatives across the country and elsewhere,

Grasslands cover nearly 40% of the Earth’s land surface and serve as important global reservoirs of biodiversity. They also provide a host of other benefits to people, termed ecosystem services, including food production, water supply, carbon storage, soil nutrient cycling, and tourism. Yet these critical ecosystems are increasingly being degraded, especially by overgrazing, heavy use of fertilisers, and climate change. This is undermining their ability to support biodiversity and deliver other benefits, such as carbon storage and nutrient retention.

The team of scientists show that using single restoration interventions often leads to trade-offs among key grassland ecosystem services – for example the addition of low amounts of fertiliser boosted hay yields for livestock, but suppressed plant diversity. Also, while the addition of a seed mix alone increased plant diversity and pollination, bringing benefits for nature conservation, it did not benefit hay yield or soil carbon storage. They show that using a combination of different techniques delivers better, more balanced ecological benefits than relying on one single type of intervention.

The combined approach to grassland restoration boosted plant diversity, soil health, carbon storage, pollination, flower abundance, and forage production simultaneously, offering a clear path forward for sustainable land management.

The work was based on a long-term grassland restoration experiment set up in 1989 at Colt Park Meadows, in the Yorkshire Dales, northern England. The experiment included a range of commonly used grassland restoration interventions, including the addition of farmyard manure, low-level inorganic fertiliser, a diverse seed mix, and a nitrogen-fixing red clover, which were tested individually and in all possible combinations. Over several years, between 2011 and 2014, the team measured 26 critical ecosystem functions related to hay yield, soil carbon storage, soil nutrient cycling, soil structure, water quality, pollinator visitation, and plant diversity.

Dr Shangshi Liu, the lead author of the paper from 17�Թ��� and now based at Yale, said: “Single solutions are rarely enough—we need landscapes that work on many levels: for climate, for people, and for nature. By layering complementary actions that target different components of the ecosystem, we can restore a broader suite of ecosystem functions—balancing trade-offs and minimising unintended consequences.”

Professor Richard Bardgett, who initiated the study at 17�Թ��� and recently moved to Lancaster, added: “These findings evidence the potential of combining interventions to boost the restoration of degraded grasslands. By combining interventions, such as adding more diverse plant seeds, small amounts of fertiliser, manure and red clover, we show that it is possible to balance hay yields for livestock as well as boosting biodiversity, carbon storage, and wild flower abundance, although each combination will need to be tailored for specific sites. These findings represent a shift from conventional approaches that typically rely on single management interventions.

“In doing so, they offer a blueprint for land managers and policymakers seeking to deliver multiple benefits from grassland restoration, which aligns the UN Decade on Ecosystem Restoration (2021–2030) that calls for integrated solutions to ecological degradation.”

The researchers also call for further experimentation across different climates and grassland types, alongside policy frameworks that incentivise grassland restoration. Programmes that currently support single interventions for grassland restoration could be restructured to favour integrated approaches that deliver broader ecological returns of benefit to a wider range of land users.

Ben Sykes, Director of the Ecological Continuity Trust (ECT), who work to secure long-term experiments such as Colt Park, said: “The Colt Park Meadows long-term grassland restoration experiment, running since 1989, is one of many decades-long ecological field experiments (LTEs) across the UK that are linked via the ECT’s national register of experimental sites. These latest results from the Colt Park LTE help demonstrate the irreplaceable value of LTEs in providing the real-world scientific evidence needed to promote conservation, biodiversity restoration and future effective and sustainable land management.”

The study was funded by the UK Department of Environment, Food and Rural Affairs and Natural Environment Research Council (NERC), and benefits from long term support from Natural England.

The study’s findings are detailed in the paper ‘Multiple targeted grassland restoration interventions enhance ecosystem service multifunctionality’ which has been published by .

DOI: 10.1038/s41467-025-59157-8

In a Wellcome funded study published today (01/05/25) in Science - one of the world’s leading scientific journals – the researchers challenge conventional wisdom taught in schools for over 100 years.

Students are currently taught that during cell division, a ‘parent’ cell will become spherical before splitting into two ‘daughter’ cells of equal size and shape.

However, the study reveals that cell rounding is not a universal feature of cell division and is not how it often works in the body.

Dividing cells, they show, often don’t round up into sphere-like shapes. This lack of rounding breaks the symmetry of division to generate two daughter cells that differ from each other in both size and function, known as asymmetric division.

Asymmetric divisions are an important way that the different types of cells in the body are generated, to make different tissues and organs.

Until now, asymmetric cell division has predominantly only been associated with highly specialised cells, known as stem cells.

The scientists found that it is the shape of a parent cell before it even divides that can determine if they will round or not in division and determines how symmetric, or not, its daughter cells are going to be.

Cells which are shorter and wider in shape tend to round up and divide into two cells which are similar to each other.  However, cells which are longer and thinner don’t round up and divide asymmetrically, so that one

daughter is different to the other.

The findings could have far reaching implications on our understanding of the role of cell division in disease. For example, in the context of cancer cells, this type of ‘non-round’, asymmetric division could generate different cell behaviours known to promote cancer progression through metastasis.

Harnessing this information could also impact regenerative medicine, enabling us to better manufacture the cell types needed to regenerate damaged tissues and organs.

Scientists may one day be able to influence the function of daughter cells by simply manipulating their parental cell shape.

Co-lead author Dr Shane Herbert, a senior research fellow at 17�Թ��� said: “The phenomenon of mitosis - or cell division - is one of the fundamentals of life and a basic biological concept which is taught from school age.

“Students learn that when a cell divides, it will generate a uniform spherical shape. Our study, however, shows that in real living organisms, it is not as simple as that.

“Our research suggests that the shape of the cell before it divides can fundamentally direct whether a cell rounds, and importantly, if its daughters are symmetric or asymmetric both in size and function.”

The scientists used real time imaging to study the formation of blood vessels in 1-day old transparent zebrafish embryos.

Growing blood vessels and other tissues are made of strands of collectively migrating cells.

Each new vessel is led by a special fast-moving cell at the front with slower cells following behind.

When the fast moving “tip” cell divided, the study showed, it didn’t “round-up” as expected. In doing so it was able to divide asymmetrically and generate the new fast “tip” cell at the front and a slower following cell behind it.

Co-lead author Dr Holly Lovegrove, a lecturer at 17�Թ��� said: “Using transparent 1-day old zebrafish embryos allows us to study a dynamic process like cell division inside a living organism.

“We are therefore able to make movies of this fundamental cell behaviour and in doing so reveal exciting new aspects of how tissues grow.”

The team also used a technique using human cells called micropatterning.

Co-First author Dr Georgia Hulmes, a Postdoctoral Research Associate at 17�Թ��� said: “Micropatterning allows us to generate specifically shaped microscopic patches of proteins that cells can stick to.

“The cells will then take the shape of the patch. This therefore allows us to change the shape of the cells and test how these shapes impact on the subsequent cell division.”

The micropatterning system used by the scientists is called PRIMO by Alvéole. This system allowed the scientists  to manipulate cells into different shapes at tiny resolutions of less than a tenth of the width of a human hair. A UV laser is used to burn specific shapes onto a non-sticky surface. Cells are then seeded onto the surface and will only be able to stick down in areas where the UV laser has printed a shape. The cells then spread out into the laser patterned shape and this allowed the scientists to create the precise shape of cell they desire.

• Video shows cells with membrane and nucleus labelled undergoing division, copyright University of 17�Թ���
• The paper Interphase cell morphology defines the mode, symmetry, and outcome of mitosis, is published in Science.

17�Թ��� is globally renowned for its pioneering research, outstanding teaching and learning, and commitment to social responsibility. We are a truly international university – ranking in the top 50 in a range of global rankings – with a diverse community of more than 44,000 students, 12,000 staff and 550,000 alumni from 190 countries.  Sign up for our e-news to hear first-hand about our international partnerships and activities across the globe. 

The three-year programme, which will be piloted in the North West before eventually being rolled out across the UK, aims to make the subject more accessible to students from a wider range of backgrounds. The training will be made available at no cost to the teachers or schools.

Economics is currently offered as an A Level subject at just over half of non-selective state schools in England, compared with 90% of selective schools and 82% of independent schools. This partly reflects a shortage of qualified economics teachers – made worse by very low levels of new teachers choosing to specialise in the subject.

, Vice President and Dean of the Faculty of Humanities at 17�Թ���, said: “The teaching, research and development of economics has a long history at 17�Թ���. Our commitment to equity and diversity across our work is paramount, and this initiative, building on the research from FFT Education Datalab, highlights that we still have much to do. We’re extremely proud to work alongside the Bank of England in producing more teachers of economics.”

, University Academic Lead for Lifelong Learning, Flexible Learning Programme at 17�Թ���, said: “At 17�Թ���, we are passionate about creating flexible, lifelong learning opportunities to help individuals, organisations and sectors adapt to an ever-changing world. This collaboration with the Bank of England offers flexible professional learning to bridge the gap in teaching economics. Our first cohort of teachers starts in September with plans to roll the programme out across the UK in the coming years.”

The launch comes as new research commissioned by the Bank of England and carried out by FFT Education Datalab revealed that:

• Economics has become increasingly popular at A Level and undergraduate level over the last decade.
• There are stark regional differences in participation with students in London more than twice as likely to study economics than those in North-West England.
• Students from disadvantaged backgrounds are far less likely to take economics at school or university than their peers.
• Around 70% of those studying economics at school and undergraduate level are male.

Clare Lombardelli, Deputy Governor for Monetary Policy at the Bank of England, spoke at the launch of the research at 17�Թ���. She talked about her own experience growing up in nearby Stockport where she studied economics A Level at a local sixth form college.

She said: “Economics is an increasingly popular subject. But it is not available to enough young people across a range of backgrounds.

“An economics qualification can be a gateway for young people to a highly rewarding career – both intellectually and professionally. It also gives people a better understanding of how money works – which is a vital life skill that can benefit all of us.

“We are delighted to be working with 17�Թ��� on this teacher training programme so economics can tap into a broader range of talent and more people can benefit from the opportunities that come from studying economics.”

Gareth Taylor, Head of Professional Development at the Economics, Business and Enterprise Association, which represents economics teachers, said: “There is clear evidence that a shortage and unequal spread of teachers with the knowledge and skills to teach economics is impacting the life chances of young people. This much-needed new programme will enable more schools and colleges to offer economics and is an exciting and very welcome development.”

The full report is available to download at

Teachers interested in signing up to the programme are asked to complete an .

36,000 runners took part in the 26.2-mile race which started at Old Trafford football stadium, looping down to Stretford, Sale, Altrincham, Baguley, Sale Moor, Chorlton, Whalley and Hulme before finishing on Oxford Road.

The adidas 17�Թ��� Marathon’s conclusion at 17�Թ��� was new for 2025, with the historic university chosen to close off the race in recognition of its buildings’ grandeur and its reputation as a hub of innovation and progress.

James Marenghi, Head of Sport & Physical Activity at 17�Թ��� said: “A huge congratulations to all those who took part in the 17�Թ��� Marathon on Sunday, I hope you enjoyed the experience and feeling of achievement as you crossed the finish line. Whilst it was great to get a feel for the atmosphere across the route, it was fantastic to see the thousands of participants and spectators under the iconic University arches at the finish line celebrating their successes.

“At the University, sport and physical activity is extremely important for our community’s wellbeing and we are delighted to have supported such a fantastic event that will enable a positive health benefit to our students, staff and local region. We hope that everyone involved is inspired to continue their fitness journey beyond this event and make the most of the other opportunities available through the University to stay active.”

The University was also chosen to backdrop the finish line this year to allow runners a better post-finish experience, with the University perfectly situated among bars, restaurants, shops and transport options.

Members of staff at the University took part in the challenge including James Spearing, Change Communications Officer, who ran to raise money for Breast Cancer UK.

He said after the event: “I enjoyed my run today as part of a four-person relay team and raising money for charity. I love having events like this on my doorstep in 17�Թ���.

“What made it even better this year was how the new finish line was able to showcase The University’s beautiful architecture as another iconic location in the city - it’s not all about Old Trafford!”

Kirsty Wilde, Director of Operations at A.S.O. UK, said: "This year’s event was truly exceptional, culminating in a breathtaking new finish line on Oxford Road set against the iconic backdrop of the University of 17�Թ���. Welcoming 36,000 participants to the event was a proud moment for everyone involved.

“We are grateful to 17�Թ��� for their ongoing support in helping us to deliver one of Europe’s largest marathons, and we look forward to building on this and to working with them in the years to come."

17�Թ��� has been at the heart of the city of 17�Թ��� for two centuries and it celebrated its bicentenary in 2024.

Key Findings

• Contrary to common belief, and consistent with other recent large-scale studies, loneliness decreases with age. 29% of Gen Z feel lonely compared to 14% of Baby Boomers and the Silent Generation. Yet, most interventions still focus on the elderly — highlighting a gap for products, services, and workplace cultures that prioritise belonging amongst young people.
• Perhaps surprisingly, more than 50% of people find positive alone time a helpful way of overcoming loneliness — revealing a powerful opportunity for businesses to design environments, products, and experiences that support solitude, not just social interaction.
• 14% of people who completed the survey say they have nowhere to go when they feel lonely, but want to connect with others — a clear opportunity for businesses to create connection-friendly spaces in places such as cafés, retail stores, and offices.
• 60% report experiencing ‘relational’ or ‘collective’ loneliness, not just ‘intimate’ loneliness — opening the door for brands to design experiences that foster everyday social connection.
• People not belonging to a group are 1.6x more likely to feel lonely — giving businesses a chance to build community through memberships, loyalty programs, and shared identity experiences.
• Dissatisfaction with income doubles the likelihood of loneliness, regardless of actual earnings — suggesting companies can drive loyalty and retention among their workforce by improving perceived financial well-being, not just financial status.

The report launch invites purpose-driven business leaders to join the Business vs. Loneliness change platform, working together with public and non-profit partners to help create a more connected world through business.

To access the report and for more information, visit . 

The compound, developed by the scientists and known as caADAMTS13, could be a breakthrough for patients who have brain blood clots with an overabundance of platelets-  the tiny cell fragments that help form clots and are often not treatable by existing therapies. 

The study, funded by a British Heart Foundation 4-Year PhD Studentship Program and 17�Թ��� Innovation Factory is published in the leading journal in the field, Stroke. 

It is the first potential new treatment for stroke in the UK since the clotbusting drug recombinant tissue plasminogen activator (rtPA) was licensed in September 2002. 

According to existing research, rtPA is only effective in as few as 10% to 35% of patients and is associated with a significant risk of bleeding. 

Another clotbuster called Tenecteplase (TNK), a variant of rtPA, was recently approved for the treatment of acute ischemic stroke in the United States but has similar limitations to rtPA. 

Both rtPA and TNK have similar efficacy and risk of haemorrhage. 

Von Willebrand Factor (VWF), a protein involved in blood clotting, helps platelets stick to damaged blood vessels and form the structure of blood clots. 

The greater the proportion of platelet and VWF components in a clot, the less effective rtPA is in dissolving it. 

The scientists investigated an alternative strategy which utilises caADAMTS13, an enzyme that reduces the size of VWF and helps break down blood clots. 

In previous mouse studies they have already shown that caADAMTS13 improves cerebral blood flow, reduces damage in the brain, reduces the depositing of both platelets and a clot promoting protein called fibrin, as well displaying anti-inflammatory properties. 

However, until now, a head to head comparison with the existing therapies of rtPA and  TNK had not been carried out. 

The scientists directly compared caADAMTS13 with rtPA and TNK in mice with a cerebral artery blockage from platelet and VWF rich clots, to mimick rtPA-resistance. 

They found that the restoration of cerebral blood flow 1 hour after treatment was the greatest in the mice treated by caADAMTS13 and that at 24 hours the caADAMTS13 mice had reduced brain damage.

Lead author Lucy Roberts, from 17�Թ���, said: “When someone has an acute ischemic stroke, doctors need to quickly remove the clot blocking cerebral arteries in the brain.

“To avoid  severe and potentially life-threatening complications, the need to act fast is acute. Unfortunately, current treatments are only sometimes effective.

“However, our findings show that the compound we developed, called caADAMTS13, is more effective than current stroke treatments

“That is why it is tremendously exciting that this compound could one day meet an unmet clinical need for stroke patients.”

Co-author and principle investigator Professor Stuart Allan from 17�Թ��� said: “We know that removing blood clots can improve outcomes in stroke and that current treatments don’t always work.

“Therefore, the approach is proven to work and we just need better drugs that can break down all types of blood clots. We think caADAMTS13 may allow this to happen.”

Professor Bryan Williams, Chief Scientific and Medical Officer at the British Heart Foundation, said: "A stroke is a medical emergency. For every minute blood flow to the brain is disrupted during a stroke, millions of nerve cells can become damaged and die. Stroke remains the single biggest cause of severe disability in the UK and we urgently need new treatments.

“More research will be needed to understand how these early results in mice can be translated to humans, but this study gives us a promising glimpse into a future where the compound caADAMTS13 could potentially be developed as a new therapy to safely and effectively dissolve blood clots in the brain.”

The paper Comparison of the Novel Thrombolytic Constitutively Active ADAMTS13 With Clinical Thrombolytics in a Murine Stroke Model , DOI: 10.1161/STROKEAHA.125.050848, is available

• The  video animation  illustrates the formation of a clot. Please credit the .
• For the image of the brain, please credit the .

For over 30 years Professor Itzhaki, professorial fellow emerita, University of 17�Թ��� and visiting professorial fellow, University of Oxford, has pursued the idea that HSV1, the herpes virus that causes cold sores, is a precursor to the development of AD. 

The 2025 STATUS List features 50 influential people shaping the future of health and life sciences across biotech, medicine, health care, policy, and health tech. 

The list is wide-ranging: from the biotech and health system executives who lead the market, to scientists developing AI technologies and breakthrough therapies, to patient advocates and activists.  

At  the University of 17�Թ���, Professor Itzhaki’s team discovered that HSV-1 DNA is present in the human brain in a high proportion of older people - the first microbe to be detected definitively in normal human brains.

The researchers later indicated that the virus when in the brain, in combination with a specific genetic factor, confers a high risk of developing AD.

She recently co-authored a that suggested that repeated head injuries could reawaken dormant HSV1 virus in the brain, triggering the onset of the disease.

The research team found that even mild brain trauma can trigger this chain reaction, leading to harmful changes associated with memory loss and cognitive decline.

The idea is winning purchase as the “amyloid hypothesis” — which proposes that Alzheimer’s is caused by a protein buildup in the brain — loosens its grip on the scientific community.

The researchers hope their work will pave the way for new treatments to protect against neurodegeneration, particularly for those at high risk due to repeated concussions.

Professor Itzhaki said: “I am delighted to be included in this year’s STATUS list. It is a great honour and a recognition that my work is finally being accepted by the scientific community.

“Most people now accept that dormant Herpes Simplex Virus in the brain  can become reactivated and in so doing can trigger the symptoms of Alzheimer’s Disease.”

Enzymes are proteins that catalyse chemical reactions, turning one substance into another. In labs, scientists engineer these enzymes to perform specific tasks like the sustainable creation of medicines, and materials. These biocatalysts have many environmental benefits as they often produce higher product quality, lower manufacturing cost, and less waste and reduced energy consumption. But to find ‘the one’, scientists must test hundreds of variants for their effectiveness, which is a slow, expensive, and resource-intensive process.

Research conducted by 17�Թ��� in collaboration with AstraZeneca is changing this. The team developed a method for a technique that can test enzyme activity up to 1,000 times faster than traditional methods. The new method, developed over the last eight years and detailed today in the journal  is called DiBT-MS (Direct Analysis of Biotransformations with Mass Spectrometry).

It builds on an existing technology called DESI-MS (Desorption Electrospray Ionization Mass Spectrometry), a powerful tool that allows scientists to analyse complex biological samples without the need for extensive sample preparation. 

By making small adaptations to the technology, the scientists designed a protocol to directly analyse enzyme-triggered chemical reactions, known as biotransformations, in just minutes. The new method can process 96 samples in just two hours—tasks that would previously take days using older techniques.

It has also been optimised to allow the researchers to reuse sample slides multiple times improving testing efficiency and decreasing the use of solvents and plasticware.

The team has already successfully applied this technique to a range of enzyme-driven reactions, including those enzymes particularly valuable in the development of therapeutics.

Looking ahead, 17�Թ��� will continue to explore ways to boost partnerships between laboratories and tackle other challenges that often hinder collaboration, such as geographical barriers and limited funding.

This research was partly funded by a UKRI Prosperity Partnership grant in collaboration with AstraZeneca.

Journal: Nature Protocols

Full title: Direct analysis of biotransformations with mass spectrometry—DiBT-MS

DOI: 10.1038/s41596-025-01161-9

Link:

“The other circumstance for unwanted behaviour was while they were working in their first part-time job as a teenager, with adult male customers making sexual or otherwise inappropriate comments to them while they were working. A young girl working her first job probably isn’t going to feel able to challenge this behaviour or speak to someone about it.”

Ms McFalone also carried out interviews with affected women. One told her she was 13 years old when she first was “cat-called in a school uniform” by “fully grown men.” Another said: “I worked for a pizza place as my first job – surprisingly the worst sort of male attention I got, which was borderline illegal, was when I was 15.”

The Breakthrough Prize – popularly known as the “Oscars of Science” – honours scientists driving remarkable discoveries. 

CERN’s four major LHC experiment collaborations — , , , and  — have been recognised for testing the modern theory of particle physics – the Standard Model – and other theories describing physics that might lie beyond it to high precision.

In particular, the team have been awarded for discoveries made during the LHC Run-2 data up to July 2024, including detailed measurements of Higgs boson properties, the discovery of new particles, matter-antimatter asymmetry and the exploration of nature at the shortest distances and most extreme conditions.

17�Թ��� researchers are involved in two of the four projects, ATLAS and LHCb. ATLAS is designed to record the high-energy particle collisions of the LHC to investigate the fundamental building blocks of matter and the forces governing our universe in order to better understand building blocks of life, while LHCb focuses on investigating the slight differences between matter and antimatter.

, Head of Physics and Astronomy at 17�Թ��� and former leader of the LHCb experiment explained that for his experiment “the department constructed a silicon pixel based ‘camera’ for the new version of the experiment that takes images 40 million times per second. Members played significant roles in the discovery of new matter antimatter differences and the discovery of new particles”.

The four LHC experiment collaborations involve thousands of researchers from over 70 countries. The $3M award was collected at a ceremony in LA by Parkes’ successor as leader of the experiment along with the leaders of the other three experiments.

Following consultation with the experiments’ management teams, the Breakthrough Prize Foundation will donate the $3 million Prize to the . The Prize money will be used to offer grants for doctoral students from the collaborations’ member institutes to spend research time at CERN, giving them experience in working at the forefront of science and new expertise to bring back to their home countries and regions.

Going forward, the LHC experiments will continue to push the boundaries of knowledge of fundamental physics to unprecedented limits. The upcoming upgrade of the Large Hadron Collider, the High-Luminosity LHC, which many of 17�Թ���’s physicists and engineers are involved in, aims to ramp up the performance of the LHC, starting in 2030, in order to increase the potential for discoveries.

The researchers suggest that policymakers should increase funding so that deprivation is taken into account as a factor in general practice funding to address income disparities between GPs in more deprived and less deprived areas.

Published in the today (22/04/25) and funded by the , the researchers analysed data from over 8,500 GPs between 2015 and 2021 in the GP work life

They looked at the relationship between deprivation of practice population and job pressures, job satisfaction, reported income, working hours, and intentions to leave direct patient care.

The lead researcher is , an NIHR Clinical Lecturer at 17�Թ��� and practicing GP.

He said: “This study shows how the socioeconomic deprivation of practice populations in England is adversely linked to the working conditions of the GPs that work there.

“We highlight a clear and persistent challenge in ensuring equitable healthcare provision.

“Without targeted investment and policy interventions, the difficulties faced by GPs in deprived areas will only continue to worsen, exacerbating health inequalities.”

Key Findings also included:

• GPs in the most deprived areas earn less than those in wealthier areas with an average difference of £5,525 less per year.
• Despite higher job pressures, there were no differences in overall job satisfaction, hours worked per week, or intentions to leave patient care between GPs working in more deprived and less deprived areas.

from 17�Թ���, senior author of the study, added: “Though deprived populations have higher needs for GP services, we know these areas have the most difficulty recruiting and retaining GPs.

“Our study is the first to examine how working in deprived areas affects the working lives of GPs. Addressing their concerns about increased job pressure and decreased resources would help reduce health inequalities.”

According to the researchers, the findings explain why working in areas of greater deprivation is less attractive to GPs, exacerbating workforce recruitment and retention issues.

Dr Anderson added: “Alongside financial incentives, non-financial incentives such as enhanced career development opportunities including fellowships that incorporate time for additional training, research, and leadership responsibilities could be a useful lever to promote GP recruitment and retention in areas of greater deprivation”.

“We also think it’s important to acknowledge we find no differences in hours worked per week, job satisfaction, and intention to quit direct patient care in more deprived and less deprived areas.

“Despite the challenges experienced by GPs working in areas of greater deprivation, this suggests that there are many rewarding aspects of working in areas of greater deprivation.  A broader recognition by the GP community of the potential advantages of working in areas of greater deprivation would therefore be helpful to promote recruitment and retention.”

This article reports the findings from independent research commissioned by the Department of Health and Social Care and carried out by the Policy Research Unit in Health and Social Care Systems and Commissioning (PRUComm). The research was conducted by the Health Organisation, Policy, and Economics (HOPE) group within the Centre for Primary Care & Health Services Research at 17�Թ���. The study was funded by the National Institute for Health and Care Research (NIHR) Policy Research Programme. The views expressed are those of the authors and not necessarily those of the Policy Research Programme, NIHR, or the Department of Health and Social Care

• Deprivation and General Practitioners’ working lives: Repeated cross-sectional study is published in the  Journal of the , DOI: JRSM-24-0273.R2 and is available here.

The study, funded by the Jon Moulton Charity Trust, found that a dose of inhaled beclomethasone -  known as Clenil Modulite® or the ‘brown’ steroid inhaler in the UK- could lead to better clinical outcomes if taken between 3pm and  4pm.

The study was carried out in the Medicines Evaluation Unit (MEU) at Wythenshawe Hospital with support from both the National Institute for Health and Care Research (NIHR) 17�Թ��� Biomedical Research Centre (BRC) and the NIHR Oxford Health BRC.

It is the first to show the effect of coordinating a commonly used asthma treatment with the body's circadian rhythms – or body clock-  on daily physiological and immunological changes.

It follows on from a 2023 by the research team which  demonstrated enhanced steroid sensitivity in immune cells at 4PM compared to 4AM.

It also supports the theory that the onset of the inflammatory cascade  - a complex series of chemical reactions occurring  within the body leading to inflammation and healing - begins  in the mid-afternoon.

According to Asthma +Lung UK, around 7.2 million Brits have asthma or 8 in every 100 people.

People with asthma suffer from wheezing, breathlessness, and a cough or a tight chest  which are triggered by things like exercise, allergens or changes in weather.

At the moment there is no cure for asthma, though most people with asthma can control their symptoms using asthma inhalers and other medicines.

The study, published in Thorax (16/04/25), was led by Dr Hannah Durrington, Senior Clinical Lecturer and MRC Clinician Scientist at 17�Թ��� and honorary consultant physician at 17�Թ��� University NHS Foundation Trust , along with Dr Ran Wang, an NIHR Clinical Lecturer, also at the University of 17�Թ���.

Dr Durrington said: “Up to three quarters of patients experience worsening symptoms overnight and up to 80% of fatal asthma attacks occur at night.

“This study shows that aligning the timing of beclomethasone – ‘the brown inhaler’ a commonly taken asthma treatment  - with the body clock could have significant impacts on treatment outcomes.

“And this occurred without any of the associated adverse effects or costs of taking higher doses of steroids.

“Our findings warrant further validation in a larger clinical trial to establish clinical feasibility in a real-life setting and to evaluate the health and economic impacts.”

The 21 patients in this cross-over study received the 400µg dose once-daily between 8AM and 9AM; once-daily between 3PM and 4PM; and 200µg twice-daily between 8AM and 9AM and between 8PM and 9PM- the ‘usual’ pattern of dosing in the UK.

All patients received the three regimes in a randomized order for 28 days, with a 2-week washout period between treatment periods.

The scientists tested lung function and blood eosinophil counts -a key biomarkers for airway inflammation - and serum cortisol levels to assess health outcomes.

The mid-afternoon dose resulted in the largest increase in overnight lung function and a significant  overnight suppression in blood eosinophil counts compared to once-daily morning and standard twice-daily dosing regimes.

Dr Durrington added: “Our findings provide key opportunities for novel chronotherapeutic development in asthma, leading to the possibility of tailored therapy based on individuals’ preference in timing of drug administration and their biological rhythm in disease.”

The paper The impact of dosage timing for inhaled corticosteroids in asthma: a randomised 3-way crossover trial is published in , DOI/10.1136/thorax-2024-222073

Between 2011 and January of this year, 114 spinout companies were tracked for 17�Թ��� in data produced by the Royal Academy of Engineering and Beauhurst.   

There has been a significant rise (32.6%) in the number of 17�Թ��� spinouts since the last report, jumping from 86 to 114. Eight additions were due to the revised HESA definition of what constitutes a spinout.  

The University’s Technology Transfer Office, 17�Թ��� , has been at the forefront of spinout generation at the University, helping to bring ideas to life by licensing intellectual property (IP) and making an impact on industry.  

Catherine Headley, CEO of the Innovation Factory, said: “With many years of experience delivering commercialisation from 17�Թ���’s research and intellectual property, we are proud to play a key role in the University’s impressive ranking as a top-tier institution for spinout generation.  

“The Innovation Factory is excited to build on the success of the more than 100 existing spinout companies we have created from the University’s academic research, driving further innovation and impact for the region and beyond.”   

The report highlighted how the ‘Golden Triangle’ of Oxford, Cambridge and London, the UK’s research and development (R&D) cluster, accounts for 27.7% of the total spinout population.   

17�Թ��� fell just behind Imperial College London (132) for number of spinouts, with the University of Cambridge (175) and University of Oxford (225) taking the second and first spots respectively.  

The report also highlighted the top sectors by number of spinouts, with pharmaceuticals (399), data provision and analysis (282) and electronics hardware (269) making up the top three. The highest emerging sectors in this report include artificial intelligence (214), software-as-a-service (180) and CleanTech (169).  

In keeping with 17�Թ���’s innovation drive, the University of 17�Թ��� recently established its new innovation capability, , to connect and catalyse the innovation ecosystem in 17�Թ��� and the wider region.  

By making the University’s world-class research, innovation assets and talent more accessible to all, Unit M is attracting and growing innovation-intensive businesses in the region. It is designed to address all aspects of the innovation challenge – from R&D and innovation adoption through to talent and skills – creating an economy that creates good jobs, higher pay, and improved productivity, alongside supporting and nurturing spinout talent.  

Professor Lou Cordwell OBE, CEO of Unit M, said: “17�Թ��� has long been the innovation engine of the city, making it no surprise that it has ranked so highly for spinout generation.  

“This stellar track record has paved the way for Unit M to drive a more inclusive model of innovation-led growth, bridging the gap with other participants in the innovation economy. This outward facing ethos will make the innovation assets and talents of the University more accessible to all - enabling 17�Թ��� to fulfil its economic potential and supercharge growth both regionally and nationally.” 

Researchers at 17�Թ��� have developed a ground-breaking method to precisely measure the strength of hydrogen bonds in confined water systems, an advance that could transform our understanding of water’s role in biology, materials science, and technology. The work, published in , introduces a fundamentally new way to think about one of nature’s most important but difficult-to-quantify interactions.

Hydrogen bonds are the invisible forces that hold water molecules together, giving water its unique properties, from high boiling point to surface tension, and enabling critical biological functions such as protein folding and DNA structure. Yet despite their significance, quantifying hydrogen bonds in complex or confined environments has long been a challenge.

“For decades, scientists have struggled to measure hydrogen bond strength with precision,” said , who led the study with and Dr Ziwei Wang. “Our approach reframes hydrogen bonds as electrostatic interactions between dipoles and an electric field, which allows us to calculate their strength directly from spectroscopic data.”

The team used gypsum (CaSO₄·2H₂O), a naturally occurring mineral that contains two-dimensional layers of crystalline water, as their model system. By applying external electric fields to water molecules trapped between the mineral’s layers, and tracking their vibrational response using high-resolution spectroscopy, the researchers were able to quantify hydrogen bonding with unprecedented accuracy.

“What’s most exciting is the predictive power of this technique,” said Dr Yang. “With a simple spectroscopic measurement, we can predict how water behaves in confined environments that were previously difficult to probe, something that normally requires complex simulations or remains entirely inaccessible.”

The implications are broad and compelling. In water purification, this method could help engineers fine-tune membrane materials to optimise hydrogen bonding, improving water flow and selectivity while reducing energy costs. In drug development, it offers a way to predict how water binds to molecules and their targets, potentially accelerating the design of more soluble and effective drugs. It could enhance climate models by enabling more accurate simulations of water’s phase transitions in clouds and the atmosphere. In energy storage, the discovery lays the foundation for “hydrogen bond heterostructures”, engineered materials with tailored hydrogen bonding that could dramatically boost battery performance. And in biomedicine, the findings could help create implantable sensors with better compatibility and longer lifespans by precisely controlling water-surface interactions.

“Our work provides a framework to understand and manipulate hydrogen bonding in ways that weren’t possible before,” said Dr Wang, first author of the paper. “It opens the door to designing new materials and technologies, from better catalysts to smarter membranes, based on the hidden physics of water.”

This research was published in the journal Nature Communications.

Full title: Quantifying hydrogen bonding using electrically tunable nanoconfined water

DOI: 

The research was supported by the European Research Council and UK Research and Innovation (UKRI).

The is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at 17�Թ���, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field – a community of research specialists delivering transformative discovery. This expertise is matched by £13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

The University and the Santa Clara-based company have signed a Memorandum of Understanding (MoU), marking a strategic partnership aimed at leveraging the strengths of both organisations to drive advancements in AI applications across multiple sectors, including healthcare, social care, education, and sustainability. 

This collaboration will provide a foundation for joint research projects, academic exchange programs, and curriculum development initiatives that will shape the future of AI-driven solutions.  

Under the terms of the MoU, the partnership will focus on key initiatives, including:  

Research and Development in AI, Robotics, and Automation – Exploring applications of AI in healthcare, education, and sustainability, including the development of AI-powered robotic solutions such as Fari for elderly care and Senpai for special needs education.   

AI for All Initiative – Facilitating upskilling and workforce development programs in AI and robotics for healthcare, social care, and education professionals.  

Joint Degree Programs and Curriculum Development – Establishing specialized programs in AI, robotics, and automation, incorporating theoretical and practical components with hands-on experience using InGen Dynamics’ technologies, including Fari, Senpai, and Origami AI.  

Social Care Testbed Collaboration – Deploying and evaluating AI-driven robotics solutions in real-world environments to improve care delivery and assess the impact of AI in social care settings.  

AI Ethics and Responsible AI Initiatives – Promoting transparency, accountability, and ethical AI development through collaborative research and policy discussions.  

Global Exchange Programs – Enabling international knowledge-sharing by connecting students and researchers from the University of 17�Թ��� with InGen Dynamics’ Futurenauts initiative in India and beyond.  

The collaboration will be overseen by a Steering Committee co-chaired by Professor Andrew Weightman, Professor of Medical Mechatronics the Department of Mechanical and Aerospace Engineering and Arshad Hisham, Founder & CEO of InGen Dynamics. The committee will meet biannually to define strategic roadmaps and identify new areas of mutual interest.  

Mr Hisham, said: “This partnership with 17�Թ��� is a significant step toward advancing AI and robotics research that has real-world impact.

“By combining our industry expertise with the academic excellence of 17�Թ���, we aim to accelerate innovation and create transformative AI solutions for global challenges.”  

Professor Weightman added: “We are excited to collaborate with InGen Dynamics to drive forward research and education in AI and automation.

“This MoU will enable us to integrate cutting-edge technology into our programs while fostering innovation that benefits society.”  

 17�Թ��� is globally renowned for its pioneering research, outstanding teaching and learning, and commitment to social responsibility. We are a truly international university – ranking in the top 50 in a range of global rankings – with a diverse community of more than 44,000 students, 12,000 staff and 550,000 alumni from 190 countries.  Sign up for our e-news to hear first-hand about our international partnerships and activities across the globe. 

#BeeWell is a youth-centred programme led by 17�Թ���, The Gregson Family Foundation and Anna Freud. The #BeeWell survey listens to the voices of thousands of young people in secondary schools every year to understand and improve their wellbeing.

China recently of the world’s largest hydropower dam, across the Yarlung Tsangpo river in Tibet. When fully up and running, it will be the world’s largest power plant – by some distance.

Yet many are worried the dam will displace local people and cause huge environmental disruption. This is particularly the case in the downstream nations of India and Bangladesh, where that same river is known as the Brahmaputra.

The proposed dam highlights some of the geopolitical issues raised by rivers that cross international borders. Who owns the river itself, and who has the right to use its water? Do countries have obligations not to pollute shared rivers, or to keep their shipping lanes open? And when a drop of rain falls on a mountain, do farmers in a different country thousands of miles downstream have a claim to use it? Ultimately, we still don’t know enough about these questions of river rights and ownership to settle disputes easily.

The Yarlung Tsangpo begins on the Tibetan Plateau, in a region sometimes referred to as the world’s third pole as its glaciers contain the largest stores of ice outside of the Arctic and Antarctica. A series of huge rivers tumble down from the plateau and spread across south and south-east Asia. Well over a billion people depend on them, from Pakistan to Vietnam.

Yet the region is already under immense stress as global warming melts glaciers and changes rainfall patterns. Reduced water flow in the dry season, coupled with sudden releases of water during monsoons, could intensify both water scarcity and flooding, endangering millions in India and Bangladesh.

The construction of has historically disrupted river flows, displaced people, destroyed fragile ecosystems and increased risks of floods. The Yarlung Tsangpo Grand Dam will likely be no exception.

The dam will sit along the tectonic boundary where the Indian and Eurasian plates converge to form the Himalayas. This makes the region particularly vulnerable to earthquakes, , and .

Downstream, the Brahmaputra is one of south Asia’s mightiest rivers and has been integral to human civilisation for thousands of years. It’s one of the world’s most sediment-rich rivers, which helps form a huge and fertile delta.

Yet a dam of this scale would trap massive amounts of sediment upstream, disrupting its flow downstream. This could make farming less productive, threatening food security in one of the world’s most densely populated regions.

The Sundarbans mangrove forest, a Unesco World Heritage Site that stretches across most of coastal Bangladesh and a portion of India, is particularly vulnerable. Any disruption to the balance of sediment could accelerate coastal erosion and make the already low lying area more vulnerable to sea-level rise.

The Brahmaputra eventually flows into a region of fertile fields and mangrove forests. Sk Hasan Ali / shutterstock

Unfortunately, despite the transboundary nature of the Brahmaputra, there is no comprehensive treaty governing it. This lack of formal agreements complicates efforts to ensure China, India and Bangladesh share the water equitably and work together to prepare for disasters.

These sorts of agreements are perfectly possible: 14 countries plus the European Union are parties to a , for instance. But the Brahmaputra is not alone. Many transboundary rivers in the global south face similar neglect and inadequate research.

Researching rivers

In our recent study, colleagues and I analysed . We wanted to assess how much academic research there was on each, what themes it focused on, and how that varied depending on the type of river. We found that, while large rivers in the global north receive considerable academic attention, many equally important rivers in the global south remain overlooked.

What research there is in the global south is predominantly led by institutions from the global north. This dynamic influences research themes and locations, often sidelining the most pressing local issues. We found that research in the global north tends to focus on technical aspects of river management and governance, whereas studies in the global south primarily examine conflicts and resource competition.

In Asia, research is concentrated on large, geopolitically significant basins like the Mekong and Indus. Smaller rivers where water crises are most acute are often neglected. Something similar is happening in Africa, where studies focus on climate change and water-sharing disputes, yet a lack of infrastructure limits broader research efforts.

Small and medium-sized river basins, critical to millions of people in the global south, are among the most neglected in research. This oversight has serious real-world consequences. We still don’t know enough about water scarcity, pollution, and climate change impacts in these regions, which makes it harder to develop effective governance and threatens the livelihoods of everyone who depends on these rivers.

A more inclusive approach to research will ensure the sustainable management of transboundary rivers, safeguarding these vital resources for future generations.

, Leverhulme Early Career Fellow, Geography,
This article is republished from under a Creative Commons license. Read the .

The finding, from CERN's LHCb experiment, which includes scientists at 17�Թ���, provides new understanding of the ‘standard Model’ of particle physics and a new piece in the puzzle to explain how and why matter ended up dominating over antimatter after the big Bang to form the Universe we see today.

The finding was presented at the Rencontres de Moriond conference in La Thuile, Italy, on 24 March and posted on .

Scientists have known since the 1960s that particles have a distinct asymmetry and can behave differently from their antimatter counterparts — a phenomenon called "CP violation." While this effect has been seen before in the break-up of certain particles, known as mesons,  this is the first time it has been definitively observed in particles similar to those of ordinary matter, known as baryons. Baryons, which include protons and neutrons, make up most of the visible matter in the Universe and consist of three quarks.

LHCb spokesperson Vincenzo Vagnoni, said: “The reason why it took longer to observe CP violation in baryons than in mesons is down to the size of the effect and the available data.

“We needed a machine like the Large Hydron Collider (LHC) capable of producing a large enough number of beauty baryons and their antimatter counterparts, and we needed an experiment at that machine capable of pinpointing their decay products. It took over 80 000 baryon decays for us to see matter–antimatter asymmetry with this class of particles for the first time.”

Every particle has an antimatter counterpart with the same mass but an opposite charge. Normally, these pairs should behave like perfect mirror images of each other. However, when particles break down or transform, such as during radioactive decay, this symmetry can be slightly distorted (CP violation). This means that matter and antimatter particles don’t always decay at the same rate. Scientists can detect and measure this tiny difference using advanced detectors and powerful data analysis techniques.

The LHCb collaboration observed CP violation in a particle called the beauty-lambda baryon (Λb), a heavier, short-lived cousin of the proton. They analysed data from millions of particle collisions collected during two runs of the LHC between 2009 and 2018 in search of a certain decay.

The team discovered that the Λb and its antimatter partner do not decay into other particles at exactly the same rate — a difference of about 2.45%. The difference is large enough to exceed the threshold physicists use to confirm an observation of CP violation. Physicists calculate that the odds of such a discrepancy occurring by chance is less than one in three million.

Chris Parkes, Professor of Experimental Particle Physics at 17�Թ��� and the former leader of the LHCb collaboration, said: “Without a difference in the behaviour of matter and antimatter there would be not matter in the universe. All the matter and antimatter would have annihilated and the universe today would be made only of light. The LHCb experiment is specifically designed to look at differences between matter and antimatter in the break-up of particles. This is a landmark discovery in these studies, as it is the first time a difference is seen in particles similar to heavy versions of the proton or neutron.”

 The CP violation predicted by the Standard Model is far too small to explain the matter–antimatter asymmetry observed in the Universe. This suggests that there may be additional, unknown sources of CP violation that scientists have yet to discover. Finding these is a key goal of research at the Large Hadron Collider and will remain a focus for future experiments.

 LHCb spokesperson Vincenzo Vagnoni, said: “The more systems in which we observe CP violations and the more precise the measurements are, the more opportunities we have to test the Standard Model and to look for physics beyond it.

“The first ever observation of CP violation in a baryon decay paves the way for further theoretical and experimental investigations of the nature of CP violation, potentially offering new constraints for physics beyond the Standard Model.”

The LHCb Collaboration is continuing its studies with the second generation version of the large experimental apparatus, key elements of which were built in the Physics and Astronomy department at the University of 17�Թ���.

Along with Anglia Ruskin University, Birmingham City University, the University of East London and the University of Warwick, 17�Թ��� will help with the adaptation of the EmilyTest GBV Charter framework for the English education system and its alignment with the new Office for Students Condition of Registration around harassment and sexual misconduct, which comes into effect as of 1 August 2025.

The Charter has already proved successful in Scotland, with 13 institutions actively engaging and 6 officially awarded.

The Charter is based on five principles: open and learning, educated and empowered, comprehensive and connected, equal and inclusive, and safe and effective.

EmilyTest was founded by Fiona Drouet after the tragic loss of her 18-year-old daughter, Emily, a law student who died by suicide following physical and psychological abuse by a fellow student while living in halls of residence.

Determined that no other victims and survivors are left under supported and at risk, Fiona established the EmilyTest charity which developed the first of its kind GBV Charter for universities and colleges. The Charter sets minimum standards in gender-based violence prevention, intervention and support, and assists institutions in asking if their policies, practices and procedures would have saved Emily’s life: ‘Would they pass the Emily test?’.

Dr Simon Merrywest, Executive Director for the Student Experience at 17�Թ��� said: “We are proud to be one of the first English universities taking part in the EmilyTest pilot following its successful run in Scotland.

“Unfortunately, gender-based violence remains a prevalent issue throughout the UK higher education system today, and we will continue to do whatever it takes to keep all of our students safe and protected both on campus and in their residences. Having got to know Fiona through a shared interest in suicide prevention, and hearing her give powerful voice to Emily’s experiences and the aims of EmilyTest, I had no hesitation in us signing up. 

“We look forward to taking part in this very worthy initiative, learning from it, and making impactful changes over the next six months and beyond.” 

17�Թ��� has an existing specialist safeguarding team, , who provide holistic, trauma-informed support to students who have experienced any form of gender-based violence, harassment or hate. The Advice and Response team is made up of specialist caseworkers who provide confidential, practical, and emotional support to students directly and signposting to statutory and other services.

The University has made campus safety a key priority, adopting the SafeZone app in recent years to allow for faster potential response times when urgent help is required on campus or in the city. The SafeZone app can be used to ‘check in’ at any time of the day, quickly and discreetly call for assistance, and get medical help quickly.

17�Թ��� has also partnered with its Students’ Union to provide sexual violence support drop-in sessions which are open to anyone looking for support.

Funded by the Biotechnology and Biological Sciences Research Council (BBSRC), the study on mice shows that the brain’s hypothalamus controls how the immune system adapts during fasting, through a handful of highly specialized neurons responsible for making animals hungry.

Published today (04/04/25) in —one of the world’s leading immunology journals—the study shows the brain’s perception of hunger or fullness, rather than actual eating or caloric restriction, is enough to drive changes in the body’s immune cells.

The findings cast doubt on the current view that a lack of nutrients alone controls how the immune system responds to fasting, indicating the brain has a critical role, beyond the simple absence of food.

By artificially switching on specific brain neurons in mice—which typically signal low energy levels—scientists induced a synthetic sense of hunger. Remarkably, within hours, they saw a fast reorganization of immune cells in the blood, with a noticeable drop in inflammatory monocytes. These artificially hungry mice looked, from an immune perspective, just like mice that had fasted for real.

This discovery could have important implications for developing new therapies to treat a range of inflammatory diseases as well as for treating wasting syndromes seen in cancer, in which individuals lose weight despite eating normally.

It may also explain why obesity often accompanies inflammatory conditions and why malnourished individuals are more prone to infections and inflammation.

The lead senior researcher, Dr Giuseppe D’Agostino, who coordinated the study, said: “Our perceptions can shape our bodies in ways we don’t always notice. It’s easy to see how thoughts guide our actions, but this study reminds us that even our internal body adjustments that are not under conscious control respond to the brain’s signals.

“This study underlines how important the brain is in regulating the immune system. But if internal or external factors alter the brain’s perception, these processes can go awry, reminding us how deeply the mind and body are—and should remain—connected.

"In addition to BBSRC who funded the work, we are grateful to the Medical Research Council for providing early-stage seed funding that helped the lab explore completely novel areas — a small but truly visionary contribution that still resonates today."

Collaborator and 17�Թ��� immunologist Professor Matt Hepworth added: “This work challenges the long-standing view that fasting’s immunological impact is driven purely by nutrient levels. It highlights the nervous system’s profound influence on how the immune system adapts during fasting.”

Lead author Dr Cavalcanti de Albuquerque said: “By showing how the brain exerts top-down control over immune cells, we can further explore when and how fasting might deliver health benefits. It also opens up potential ways to treat infectious, inflammatory, metabolic, and psychiatric conditions.”

The paper Brain Sensing of Metabolic State Regulates Circulating Monocytes   is available

Professor Cinzia Casiraghi has been appointed as Chief Scientific Officer (CSO) at the Graphene Engineering Innovation Centre (GEIC), bringing with her more than two decades of pioneering research experience in graphene and 2D materials.

Since the early 2000s, Professor Casiraghi has been at the forefront of the graphene journey. From identifying the optical fingerprint of graphene to engineering ink-jet printable 2D materials for use in electronics and biomedical applications, her work has paved the way for the development of functional, scalable applications that are now becoming reality across industries.

Casiraghi’s appointment marks a new chapter for the GEIC, which sits at the heart of the Graphene@17�Թ��� ecosystem. As CSO, she will provide strategic scientific leadership to strengthen the Centre’s role as a world-leading facility for the translation of 2D materials research into commercial products and technologies. 

She will play a key role in connecting academic expertise with industrial needs, supporting collaborative research at higher Technology Readiness Levels (TRLs), and steering the scientific direction of GEIC projects.   

Her research group at 17�Թ��� has led groundbreaking work in Raman spectroscopy of carbon-based nanomaterials, and 2D material ink formulation, with an emphasis on industry-funded projects. Her contributions to printable electronics, ranging from photodetectors, transistors and memories printed onto low-cost and biodegradable substrates, such as paper, have significantly advanced the field. Casiraghi is also a prominent advocate for cross-disciplinary research, building bridges between chemistry, physics, materials science, and engineering.

Professor Casiraghi said:

“It is an exciting time for 2D materials. I am honoured to take on the role of Chief Scientific Officer at the GEIC. For the past 20 years, I have been dedicated to graphene and 2D materials research, witnessing remarkable progress along this journey. Two decades ago, I was looking at tiny graphene flakes, produced by mechanical exfoliation, with the aim to identify their optical fingerprint.

“Today, academics and companies regularly use this framework to identify graphene. Today, we have graphene and 2D material inks that can be printed onto paper and plastic to create functional devices, or can be combined with other materials to enhance specific properties. Today, we have well-established methods for large-area deposition of graphene and 2D materials, paving the way for their integration into next-generation electronics.

“I look forward to driving innovation, advancing our research capabilities, and working alongside the team at the GEIC and the academic community to develop cutting-edge solutions. By fostering collaboration between academia and industry, we aim to demonstrate the value of 2D materials and their transformative potential.”

James Baker, CEO of Graphene@17�Թ���, said:
“Cinzia has been a driving force in the field of graphene and 2D materials research for over two decades, and her appointment as Chief Scientific Officer marks a significant development opportunity for the GEIC. Her depth of expertise, combined with a passion for innovation and collaboration, will ensure we continue to bridge the gap between fundamental science and real-world application.

“As the GEIC evolves to meet the challenges of a fast-moving innovation landscape, Cinzia’s leadership will help accelerate our mission to deliver sustainable, scalable technologies that make a meaningful impact across industry sectors.”

As CSO, Professor Casiraghi will work across the GEIC’s ecosystem — including academic departments, the National Graphene Institute (NGI), and the wider university research community — to ensure alignment of scientific vision with industrial ambition. She will lead a team of Theme Leads, drawn from disciplines including materials science and physics, to guide project direction, advise on research outcomes, and lower the barrier between industry and academia.

The role also includes high-level engagement with strategic partners and national innovation stakeholders, helping to position the GEIC as a key player in addressing global challenges around clean growth, mobility, and sustainable development. Casiraghi will support the evaluation of major project proposals, mentor scientific staff, and champion excellence in research infrastructure, collaboration, and impact.

Professor Casiraghi has held academic roles at 17�Թ��� since 2010 and currently serves as Chair of Nanoscience and Head of Materials Chemistry in the Department of Chemistry. She previously held research fellowships in Berlin and Cambridge and holds a PhD in Electrical Engineering from the University of Cambridge.

With this appointment, 17�Թ��� continues to reinforce its commitment to translating cutting-edge research into real-world impact, supporting the advancement of graphene and 2D materials through collaborative innovation and industrial engagement.

For years, nature has been blamed as a blocker of economic growth. After some ministerial about not letting get in the way of growth ambitions, the UK government released more details of its plans to .

The centrepiece of its aspirations to balance both nature and economic growth is a , to be set up in England through changes to habitat regulations. This should allow developers to stay within their legal obligations towards nature through a payment scheme without delaying their projects.

The is that, as an alternative to relocating important species or improving habitats on the site of a proposed development, a developer could pay into the nature restoration fund. This would pay for larger, more strategically located schemes to protect the species in question.

The fund simplifies and streamlines the regulations while collecting funds to promote more, bigger, better and increasingly .

Protecting nature is not just about bats and newts. According to trade association the Home Builders Federation (HBF), there are 160,000 homes being delayed by what are known as measures. These rules were a response to growing public concerns about land and water pollution caused by nutrient loads – pollutants such as nitrogen and phosphorus – associated with livestock farming and spillages from sewage works.

Government agency 74 local authorities that they should not allow any more house building in their areas unless this pollution could be mitigated. But this has led to lengthy and expensive project-by-project reviews to identify potential damage.

How will a fund help?

The fund will build on some schemes that are already known to work. One such scheme works for the protection of . Another successful scheme is project, working to protect and enhance heathland sites where rare birds such as nightingales breed. Crucially, this scheme allows new development to go ahead in adjacent areas.

The fund will be run by Natural England, which aims to draw on these experiences to unblock development at a large scale rather than at single-site level, pooling contributions from developers to pay for mitigation measures when there is a risk to nature.

If a particular “blocking” issue is identified, experts from Natural England will produce a plan, which must be approved by the environment secretary. A levy on developers will then pay for mitigation measures “in perpetuity” (often 30 years), allowing the development to get under way.

Environmental experts have the general principles and approach of the nature restoration fund. But there has also been about whether the plan is well enough thought through. There are also questions on how well it will integrate with other schemes.

A widespread worry is for the future of – which includes measures for creating and improving using biodiversity units, effectively a form of “nature market”. This approach sets a target of 10% for biodiversity improvement based upon the combined distinctness, condition and significance of affected habitats over the lifetime of the development. But these measures are only just .

The concern is that providers of sites for these habitat banks – which might be councils, landowners, charities or private businesses, for example – might get cold feet and if they can’t be certain that their plans will be compatible with the nature restoration fund.

There is concern, too, about how payments from the nature restoration fund would be calculated. These will need to be locally appropriate and not pit nature restoration and biodiversity net gain against each other if, for example, landowners are forced to choose a particular scheme for their land that they are then . With two parallel systems in play, the relationship between them must be crystal clear, otherwise shared goals could be missed.

Another question is whether Natural England can be both regulator and financial beneficiary of the new scheme. There have been calls from some of those already involved in nature markets for some form of .

And it will also be vital that the new scheme respects what’s known as the “mitigation hierarchy”. This hierarchy aims to avoid, reduce and then mitigate any impacts on nature on-site in that order. Then developers should consider off-site measures in areas where there could be greater .

But a danger here is that this could disconnect people from nature even further by mitigating ecological loss miles away from the site of the damage. This disconnection is considered to be a critical underlying cause of .

There is much to like about the nature restoration fund, but there is a risk that little will be achieved without the government showing genuine ambition and allocating enough money and staff to properly monitor and enforce it over the long term. Only time will tell whether it achieves the government’s goal of speeding up development.

At the moment, it is not clear how the fund will complement similar schemes and there is a danger of creating a complex patchwork in nature restoration funding. But if it works well, it could provide a richer funding ecosystem for nature recovery – a much-needed boost for England’s nature-depleted landscape.

, Professor, Urban and Environmental Planning and , Senior Lecturer in Planning and Environmental Management
This article is republished from under a Creative Commons license. Read the .

The findings, published in the journal ,  show that these powerful flows could be capable of traveling at speeds of up to eight meters per second, carrying plastic waste from the continental shelf to depths of more than 3,200 meters.

Over 10 million tonnes of plastic waste enter the oceans each year. While striking images of floating debris have driven efforts to curb pollution, this visible waste accounts for less than 1% of the total. The missing 99% – primarily made up of fibres from textiles and clothing – is instead sinking into the deep ocean.

Scientists have long suspected that turbidity currents play a major role in distributing microplastics across the seafloor – 17�Թ��� were among the first to demonstrate this through their research on ‘Microplastic Hotspots’ in the Tyrrhenian Sea, published in the journal . However, until now, the actual process had not been observed or recorded in a real-world setting.

The latest study conducted by 17�Թ���, the National Oceanography Centre (UK), the University of Leeds (UK), and the Royal Netherlands Institute for Sea Research provides the first field evidence showing the process.

The findings pose a significant threat to marine ecosystems and highlight the urgent need for stronger pollution controls.

Dr Peng Chen, lead author on the study at 17�Թ���, said “Microplastics on their own can be toxic to deep-sea life, but they also act as ‘carriers’ transferring other harmful pollutants such as PFAS ‘forever chemicals’ and heavy metals, which makes them an environmental ‘multistressor’ which can affect the entire food chain.”

The research focused on Whittard Canyon in the Celtic Sea, a land-detached canyon over 300 km from the shore. By combining in-situ monitoring and direct seabed sampling, the team were able to witness a turbidity current in action, moving a huge plume of sediment at over 2.5 metres per second at over 1.5 km water depth. The samples directly from the flow revealed that these powerful currents were not only carrying just sand and mud, but a significant quantity of microplastic fragments and microfibres.

Further analysis found that the microplastics on the seafloor are mainly comprised of fibres from textiles and clothing, which are not effectively filtered out in domestic wastewater treatment plants and easily enter rivers and oceans.

, Geologist and Environmental Scientist at 17�Թ���, who designed and led the research, said: “These turbidity currents carry the nutrients and oxygen that are vital to sustain deep-sea life, so it is shocking that the same currents are also carrying these tiny plastic particles.

“These biodiversity hotspots are now co-located with microplastic hotspots, which could pose serious risks to deep-sea organisms.

“We hope this new understanding will support mitigations strategies going forward.”

Dr Mike Clare of the , who was a co-lead on the research, added: “Our study has shown how detailed studies of seafloor currents can help us to connect microplastic transport pathways in the deep-sea and find the ‘missing’ microplastics. The results highlight the need for policy interventions to limit the future flow of plastics into natural environments and minimise impacts on ocean ecosystems.”

The study team are now focussing on efforts to better understand the effect that microplastics have on marine organisms, for example sea turtles and deep-sea fauna.

This research was published in the journal Environmental Science and Technology.

Full title: Direct evidence that microplastics are transported to the deep sea by turbidity currents

DOI:

The study of 15.7 million patient records, funded by the National Institute for Health and Care Research and published in the prestigious Journal of the R, implies there could be scope to prescribe far fewer antibiotics. 

The researchers found the probability of being prescribed antibiotics for a lower respiratory tract or urinary tract infection was unrelated to hospital admission risk. 

And the probability of being prescribed an antibiotic for an upper respiratory tract infection was only weakly related to hospital admission risk. 

The study also showed that patient characteristics such as age and the presence of other health problems were only weakly associated with the probability of being prescribed an antibiotic treatment of common infection. 

The most elderly patients in the sample were 31% less likely than the youngest patients to receive an antibiotic for upper respiratory infections. 

That inevitably means, say the researchers, that because many younger people are being prescribed antibiotics, even though they are often fit enough to recover without them, potentially  leading to resistance. 

Conversely,  many older people may not be able to deal with infections without antibiotics are not  receiving them, with the potential of complication and hospital admissions. 

Patients with combinations of diseases were 7% less likely than people without major health problems  to receive an antibiotic for upper respiratory infections. 

Lead authors are  Professor Tjeerd van Staa and Dr Ali Fahmi, from 17�Թ���. 

Professor Tjeerd van Staa said: “Antibiotics are effective in treating bacterial infections, but they carry the risks of antimicrobial resistance (AMR) and loss of effectiveness when used inappropriately. 

“That is why AMR to antibiotics has been recognised as one of the biggest threats to global public health. 

“Given the threat of resistance, there is a need to better target antibiotics in primary care to patients with higher risks of infection-related complications such as sepsis. 

“But this study finds that antibiotics for common infections are commonly not prescribed according to complication risk and that suggests there is plenty of scope to do more on reducing antibiotic prescribing.” 

The study also showed that the probability of being prescribed an antibiotic for lower respiratory infections was even more unrelated to complication risk during the pandemic, however they were only minor changes for urinary tract infections. 

The research team accessed anonymised patient-level electronic health records of primary care data from The Phoenix Partnership (TPP) through OpenSAFELY, a secure platform for electronic health records in the NHS. 

They included adults registered at general practices in England from January 2019 to March 2023 diagnosed with upper respiratory, lower respiratory and urinary tract infections. 

Patient-specific risks of infection-related hospital admission were estimated for each infection using risk prediction scores for patients who were not prescribed an antibiotic. 

Dr Ali Fahmi added: “Rather than imposing targets for reducing inappropriate prescribing, we argue that it is far more viable for clinicians to focus on improving risk-based antibiotic prescribing for infections that are less severe and typically self-limiting. 

“Prognosis and harm should explicitly be considered in treatment guidelines, alongside better personalised information for clinicians and patients to support shared decision making.”

“A Knowledge Support (KSS) led by Professor Tjeerd van Staa, which provides personalised information to clinicians is  now being tested in the North-West England

“We hope it could provide a workable solution to the problem of untargeted antibiotic prescribing.”

Antibiotics for common infections in primary care before, during and after the COVID-19 pandemic: cohort study of extent of prescribing based on risks of infection-related hospital admissions  is published in  DOI: 10.1177/01410768251328997

The study team at 17�Թ��� University NHS Foundation Trust (MFT) and 17�Թ��� (UoM) implemented the new technology across MFT hospitals in December 2023, which provides specialist liver care to the Greater 17�Թ��� region. The technology aims to improve early detection of hepatocellular carcinoma (HCC) – the most common cancer affecting the liver and the third most common cause of cancer death.

Developed by Roche Diagnostics, the pioneering test, known as Elecsys®GAAD, combines blood tests with gender and age, which can increase the detection rate of HCC at an early, curable stage. This is being used alongside routine surveillance tests to see how it can benefit patients, so they have the best chance of surviving this type of cancer.

One of the risks for developing HCC is a pre-existing liver disease and scarring of the liver, known as cirrhosis. Approximately 3,000 people are found to have HCC in the UK every year. Less than 1,000 are identified at a stage when they can have curative treatment, leaving over 2,000 people per year with a cancer that cannot be cured.

More than 600 patients with cirrhosis have been tested using Elecsys®GAAD within clinics at 17�Թ��� Royal Infirmary, Wythenshawe Hospital and North 17�Թ��� General Hospital, all part of MFT, and four patients have been detected with early-stage liver cancer at a treatable stage, which would not have been found without the new technology.

Gerry’s story

Father of three, Gerry, 67 was diagnosed with hemochromatosis approximately 15 years ago, a hereditary condition where the body stores too much iron, which has led to scarring on his liver, cirrhosis.

Whilst attending his routine screening appointment at Wythenshawe Hospital, Gerry joined the research trial using the Elecsys®GAAD technology, which detected the early stages of liver cancer.

Following a number of CT scans at 17�Թ��� Royal Infirmary, it was confirmed that there is a small tumour on the upper part of his liver, which he has now had removed and remains cancer free.

Gerry said: “I was shocked to find out that I had liver cancer, but also relieved that it had been found early and it hadn’t spread any further. I didn’t have any symptoms that would make me think that there was anything wrong, so I am grateful that the cancer has been caught early, where a number of treatment options are available to me.

“It isn’t until you’re in this position, that you truly realise how cancer can affect anyone, and detecting it early can save your life. I would encourage others to take part in this research trial, if given the opportunity, as this new technology will save lives. I am grateful to be in a position where curative treatment is available and I am now cancer free.”

How the technology works

In early, curable stages, HCC can have no symptoms and so it is recommended that everyone with known cirrhosis is tested every six months which involves an ultrasound scan and a blood test (alpha fetoprotein – AFP) to screen for primary liver cancer – HCC.

The new test is an algorithm used in addition to the current standard of care, which uses the AFP information alongside another blood test (Elecsys®PIVKA-II), age and gender to calculate a risk score. Data suggests that this test increases the likelihood of detecting liver cancer at an earlier stage where curative treatments are far more likely. 

Principal Investigator for the study, Dr Varinder Athwal, Consultant Hepatologist at MFT and Honorary Senior Lecturer at the University of 17�Թ���, said: “17�Թ��� has some of the highest rates of liver disease and liver cancer in the UK and far too many people are diagnosed when curative treatment is not possible.

“This innovation is a non-invasive test that easily fits into our current pathway. Early results from the project are very promising and show we are able to detect more cases of HCC at earlier, treatable stages which would have been missed by standard routine care – so it truly has the potential to save lives.

“Using this new test and with additional improvements to the surveillance pathway, we believe more than 1,000 people per year could be additionally detected at an earlier stage when their cancer is potentially curable. This number could be increased if more people are offered the test and stay in surveillance, which is something we are addressing in this project.”

Vic’s story
 

Vic joined the research trial at MFT and was detected in the early, curable stages of liver cancer and despite not being fit enough for common therapies to cure his cancer, Vic has since received a treatment called transarterial chemoembolisation (TACE) which cuts off the tumour’s blood supply with little or no effect to liver functioning.

Detecting his cancer early through Elecsys®GAAD means that it has prevented the spread of his cancer and there is currently no sign of his cancer on repeat scans.

He said: “When I agreed to join the trial, I had been being monitored routinely because of the presence of liver disease but the last thing that I thought I would ever develop was cancer. I had been stable for some years and had not experienced any new symptoms to suggest anything had changed.

“The GAAD test changed all that. The results were high and detected that I had a primary liver cancer which turned out to be a Stage 2 liver cancer. I had no symptoms. I was referred immediately for expert treatment.

“Because the GAAD test detected the cancer early I have been able to access one of several treatment options quickly, before the cancer had the chance to spread outside the liver. Early diagnosis and treatment has meant that I can also benefit from the care and support of an amazing multidisciplinary team.

“It has also meant that I have been given time to involve my family, especially my children, to navigate this journey together. Without the GAAD test, the diagnosis of cancer may have come too late for all of us.”

Through the study, researchers aim to find out if the Elecsys®GAAD test reduces unnecessary further scans and if it improves earlier detection of HCC. They will also investigate if a six-monthly ultrasound adds any further benefit to Elecsys®GAAD to detect HCC – or if Elecsys®GAAD could be used on its own, which would provide a considerable cost saving to the NHS and a significant improvement to current standard of care. 

Director of Access and Innovation at Roche Diagnostics UK and Ireland, Chris Hudson said: “Roche Diagnostics is committed to early disease diagnosis and to ensuring our innovations reach the people who need them. Working with the team in 17�Թ���, we are taking the learnings from this hugely successful trial to help other NHS Trusts implement the Elecsys®GAAD digital diagnostic solution and enable more patients with liver cancer to access timely diagnostics and potentially curative treatments.”

Dr Katherine Boylan, Director of Innovation at MFT said: “As one of the largest NHS trusts in the country, MFT is uniquely placed to test the innovation, which brings together the knowledge and expertise of academic, medical and industry partners – strengthening our position as a leader in research and innovation in the UK. We are proud to partner with Roche Diagnostics to address this unmet clinical need for the benefit of our patients, which has the potential to revolutionise early cancer diagnosis for HCC.”

Elecsys®GAAD was fast-tracked into the NHS at MFT, following £1million funding from NHS England, to test the accuracy and benefits of technology over a two-year period.

Project Managers at NHS England visited MFT alongside Roche Diagnostics, to see the progress of the project and how we are utilising the test alongside current pathways.

Dr Michael Gregory, Regional Medical Director for NHS England – North West, said: “This is a great example of how the NHS can transform health outcomes and save lives through the use of cutting-edge technology and a greater focus on prevention.

“The stories of the patients who have already benefited from this new test highlight why it is so important that we diagnose and treat cancers at the earliest possible opportunity and I’m excited to see how it could be made more widely available in the future.

“In the meantime, I would continue to encourage people with potential signs of cancer to come forward and speak to their general practice as soon as possible.”

The study is running until April 2025, recruiting more than 600 patients to the research project. Findings from the implementation at MFT will be used to co-develop a plan for the national roll out within the NHS.

This work is supported by Imperial College London who are observing the economic impact of the new technology on the NHS, and Unity Insights who are carrying out an independent evaluation of the findings across the project.

Photo: Photo: Patrick Ezean (NHS England Cancer Programme Manager), Emily Corser (NHS England Cancer Programme Manager), Dr Varinder Athwal (Principal Investigator for the study), Darren Banks (MFT Interim Deputy Trust Chief Executive), Chris Hudson (Roche Diagnostics UK and Ireland), Delphine Scokaert (Roche Diagnostics UK and Ireland), Oliver Street (Programme Manager, 17�Թ���), Dr Katherine Boylan (Director of Innovation at MFT), Laura Tornatore (Senior Programme Manager, LGC).